药学英语外文论文

研究论文中国药理学报2010年6月31期 746-752页 【数字对象唯一标识符】：吉西他滨联合顺铂治疗Ⅱ期非小细胞肺癌的临床研究范云，李能明，马胜林，罗吕红，罗芳，黄志宇，于海峰，吴凤琴摘要目的：对未接受过化疗的III期和IV期非小细胞肺癌（NSCLC）患者，静脉注射吉西他滨，d1、d5，顺铂 d1，以研究吉西他滨（dFdC）的药效学药和药代动力学。方法：一个联合治疗周期，吉西他滨1250 mg/m2，静脉输液30 min，d1、d5，每三周静脉输液一次顺铂75mg/m2，d1。两次注射间隔1hr。观察该方案的毒性反应。此外，第一次输液周期中监测不同时期的吉西他滨（dFdC）及其代谢产物（dFdU）的血药浓度。使用药代动力学软件（PKS）评价吉西他滨及其代谢产物（dFdU）药代动力学参数。结果：共有28名患者参与此项研究，平均年龄54岁（介于27~75岁之间），大多数病人的临床表现良好。27名患者接受了2个或以上的治疗周期。临床总有效率为。中位生存期13个月。估算的肿瘤进展时间(TTP)中位天数为个月，1年生存率为。毒性反应总的较轻。主要毒性为骨髓抑制；的病人出现3/4度血液学毒性，而的病人出现3/4度非血液学毒性——常见的胃肠道反应。吉西他滨及其代谢产物（dFdU）药代动力学参数在注射吉西他滨d1、d5前后无差异。在注入吉西他滨d5前，dFdU（2，2'—双氟脱氧胞嘧啶核苷）的最低浓度为± μg/mL，而吉西他滨未检测到。结论：该方案是治疗未接受过化疗的非小细胞肺癌（NSCLC）晚期患者的有效方案，总体临床耐受性良好。在静脉滴入吉西他滨，d1、d5后，吉西他滨及其代谢产物（dFdU）药代动力学参数较之前无差异，而在注入吉西他滨d5前，dFdU（2，2'—双氟脱氧胞嘧啶核苷）浓度最低。

药物药理学文献：Abstract: detoxification Vitamin Tablets (approval of the text: State Yao Zhunzi Z20026566) is a composition of compound ingredients Shisan Wei, head of its function as "Qingrejiedu, replenishing liver and kidney. Heat for leukemia drug Yung-sheng, liver and kidney Card and a lack of radiotherapy and chemotherapy-induced blood cells to reduce Dengzheng "In order to better guide clinical treatment, according to the symptoms of such disease and the characteristics of the drug, focusing on 27 and retrieval of leukemia related to pharmacology literature, and all experiments And the use of oral compound related to administration, including oral mice, gavage and in vitro experiments, the compound used in medicines and Shi Sanwei the experimental leukemia treatment. The results showed that: Liuwei with killing leukemia cells, with 10 flavor increase immune function, improve the shamisen with hematopoietic system, Bawei can inhibit the growth of pathogenic microorganisms and the taste of the two anti-fatigue effect. This is the "antidote Viacom film" The clinical application provided further evidence. Key words: "detoxification Vitamin Tablets", pharmacology, leukemia, immune function, blood system, pathogenic microorganisms, anti-fatigue, Summary Leukemia is a malignant hematopoietic system diseases. Characterized by bone marrow or other blood organizations, the WBC and a series of naive cells unrestricted dysplasia (known as leukemia cells). Invasion of the body organs and blood into the liquid, caused clinical manifestations and the surrounding blood leukocyte change. In order for patients suffering from the early, according to "Quxie, centralizer, to improve efficiency, and detoxification" Pharmacodynamic study of requirements, we antidote to Viacom-prescription medicines Shi Sanwei in the composition of the 627 study of literature, summed up the specific Are as follows: • anti-tumor effect (A), the Northeast "Guanzhong": the extract on a variety of transplanted animals inhibited the tumor, research shows that the Guanzhong B is part of an effective anti-tumor. Films detect oxygen electrode, Guanzhong B P 388 significantly reduced oxygen consumption rate of leukemia cells, mitochondria may be its anti-tumor effect of a target cell [1]. Northeast Guanzhong extract of the Northeast Guanzhong suppression of DNA synthesis, Lewis lung cancer in mice and P 388 leukemia effective. The compound used in the "Mian Ma Guanzhong" to the same family belong to the substitutes, and has since been contained in the 2000 Pharmacopoeia. (2), Qingdai: its active ingredient indirubin has anti-tumor activity, is on the clinical treatment of chronic myeloid leukemia (CML) of effective drugs. Use of radionuclide tag (3 H-TdR, 3 H-uR, 3 H-leucine), respectively incorporation of the tumor DNA, RNA and protein research shows that the method, indirubin can inhibit the slow tablets and tablets of urgency Patients with leukemia cells, W 256 solid tumors in rats, mice liver and ascites EAC cancer cell synthesis of DNA metabolism, a slight suppression of RNA synthesis, protein synthesis no significant impact [3-5]. (3), Hedyotis diffusa: its crude preparation, in vitro only in high concentration under the EAC cancer, leukemia Yoshida sarcoma and a variety of cancer cells inhibited [6-8]. (4), Scutellaria barbata: Blue Screening test-tube experiments show that the tablets cell acute leukemia (AML) have mild blood cells inhibited use of respirators screening experiments show that the blood cells of AML inhibitory rate of more than 75 % [9]. (5), Wumei: The main ingredients of this compound for chronic, such as cervical cancer tumors have a certain effect, to further confirm the anti-tumor activity on its composition and role of an effective mechanism, it was the people of the original giant leukocyte (HIM eg ) And human promyelocytic leukemia cells (HL 60) for the study, conducted in vitro. Counting from living cells and cloning experiments can be seen its rate of water and alcohol extracts of the HIMeg and HL 60 cells have a direct role in inhibiting the growth [10]. (6), artesunate: The row with law and in vitro cloning research artemisinic acid and derivatives of the four artesunate B - compounds A, B, C, D on a variety of cell lines cytotoxicity. When the four kinds of compounds concentration of 5 μ g / ml, its P 388 mouse leukemia cells inhibited the rate of more than 85% [11]. Artemisinic acid (Ⅰ) of hydroxyl in the derivatives after a ene-a-lactone of a pair of six Central to the poor vary purchase of (Ⅱ, Ⅲ), Ⅱ after a reduction in a heterogeneous in Ester (Ⅳ, Ⅴ), Ⅱ further oxidation in a post-hydroxy-lactone (Ⅵ). Compounds Ⅱ, Ⅲ and Ⅵ in vitro small P 388 leukemia cells have anti-tumor activity, and Ⅰ, Ⅳ, Ⅴ no. The concentration of 10 μ g / ml and 1 μ g / ml when, Ⅱ P 388 to inhibit cell growth rate of 100% and 42%; Ⅵ inhibition rate was 100 per cent and 47 per cent [14]. • immune function of (A), Qingdai: its active ingredient indirubin 200 mg / kg sc, for 6 d, to enhance tumor-bearing rats were swallowed up by macrophages in the role of chicken red blood cells [12]. (2), Hedyotis diffusa: mice fed with aqueous extract of its crude 0, 6g (Pharmacognosy) / only to enhance the peritoneal fluid swallowed up by white Staphylococcus leukemia in the ability of [13]. Rabbit in the ability of interleukin engulfed in bacteria, fed with water decoction group than the control group increased more than three times [14, 15]. In vitro tests can enhance people in the blood of the WBC, Staphylococcus aureus phagocytosis [16]. (C), Scutellaria barbata: The goods were obtained from the polysaccharides in vitro can promote the concanavalin A (ConA) spleen cells in mice induced lymphocyte transformation, the optimal concentration of 400 r / ml [17]. (4), Astragalus: decoction of 50%, / only ig, can accelerate the mice injected into the blood plasma protein marker 131 I dissection of the role that their organizations giant嗜the liver and spleen cells could enhance the role of phagocytosis [18 ]; Decoction of the goods 100% ml / only ig, can promote mice嗜phagocytic giant chicken RBC role [19]; decoction of the goods 25 g / kg ig, giant嗜will enhance the role of phagocytosis [20] ; Decoction of the goods 10 μ g / ml concentration of cell culture cancer patients, rats injected into the skin, significantly enhancing its local graft-versus-host reaction, that the goods on the T-cell immune function is to promote the role [21]. (5), Chinese wolfberry son: an ultra-dose sheep red blood cells (SRBC) immunoassay (SOI) show that the appropriate dose of old mice LBP inhibit T cells (Ts) significantly regulation, enhance the activity of Ts cells [22 ]. Through the Yc Rose and EA rosette forming the rate of confirmed LBP10mg/kg gavage to mice, for 7 d, can significantly increase the macrophage C 3b and the Fc receptor number and vitality, and can weaken into acetic acid Hydrocortisone on macrophage C 3b Fc receptor and the inhibition [23]. (6), artemisinin: its suspension 450 mg / kg ip, for 6 d, the sheep red blood cells in mice sensitized enhance the role of delayed-type hypersensitivity; 300 ~ 600mg/kg ip, Rose specific immune suppression in mice Flower forming, inhibit hemolytic plaque formation for the suspension of the , , in vitro and promote transformation of lymphocytes, immune cells that promote the humoral immunity and are inhibited [24]. (7), the LDC Fuling; the humoral immune response without inhibition, but the option of inhibiting cell immune response. Its water extract of the antigen sensitization after the attack and after treatment were significantly curbed Picryl chloride (pc) mice contact dermatitis and sheep red blood cells (SRBC) by the reaction of the foot, when the role of administration after the attacks more Strong. In addition, the goods on the formation of antibodies in mice SRBC cells had no significant impact, but its hemolytic plaque clearly than the control group, at the same time, the level of serum hemolysin not decreased, and was an upward trend in [25]. Fuling compound soil water, alcohol extract of gavage can inhibit the rat egg white and Carrageenan foot swelling [26]. (8), Cistanche: decoction of oral prednisolone to enhance the low Yang mice humoral and cellular immune function [27]; enhanced single-core - macrophage phagocytosis [28]; their water extract of 50 mg / kg, 100mg/kg gavage to mice, can significantly increase the weight of the spleen and thymus, enhanced macrophage phagocytosis, increase hemolysin and hemolytic plaque value, increase lymphocyte transformation rate, 3 H-TdR incorporation The increase in lymphocytes, enhanced mice delayed hypersensitivity, but also increased peritoneal macrophages in the CAMP level, lower level of CGMP, CAMP / CGMP ratio increased, this may be its enhanced peritoneal macrophages Phagocytosis one of the reasons [29]. (9), Dodder: its extract / kg ig, for 6 d, burn mice can be enhanced macrophage phagocytosis, an increase of serum antibody hemolysin spleen cells and enhance the proliferation of ConA [30]. (10), Bajitian: Wen Jinji 64 g / kg / day orally, can minors thymus atrophy, 10g/kg / day intraperitoneal injection, the thymus atrophy is also very significant, Bajitian 50 percent ethanol extract Of 60 g / kg / day of oral also make a minor thymus atrophy [31]. Its decoction, for delivery 10 days, but can inhibit the thymus atrophy and increase the number of leukocytes in the blood of the function [32]. . Microbial resistance of the role of (1), Mian Ma Guanzhong: decoction with test-tube dilution, 1: 800 to 1: 160 pairs of various types of influenza viruses have different degrees of inhibition [33]; decoction of its chicken test in 1: 104-105 Concentration of PR8 strain of influenza A virus, A virus in Asia have a strong effect [34]. (2), Qingdai: ethanol extract g / ml concentration in vitro test for Bacillus anthracis, pneumonia bacteria, Shigella dysentery bacteria, Vibrio cholerae, Staphylococcus aureus and Staphylococcus aureus are white inhibition [35]; effective Effects of one element of wool-like Microsporum, breaking the Xuanjun, red Xuanjun, floc inhibit epidermal Xuanjun, the minimum inhibitory concentration for 5 μ g / ml [36]. (C), Hedyotis diffusa: In vitro antibacterial activity is not significant, only Staphylococcus aureus and Shigella are weak role [37]. High concentrations can inhibit the water decoction of Pseudomonas aeruginosa, Salmonella typhi and Proteus the growth of many other common pathogenic role of the weak [38]. The rabbit test appendicitis a better effect [39]. (4), Scutellaria barbata: 50% decoction with flat-ditch, Staphylococcus aureus, Shigella's blessing, typhoid bacteria, pus antibacterial Green, E. coli inhibit [40]. (5), Wumei: Screening of in vitro found that inhibit a variety of pathogens such as E. coli-dysentery, typhoid bacteria, Bacillus paratyphoid, whooping cough bacteria, such as meningococcus [41-45]. (6), Astragalus: decoction of 50% / only ig, for 2 d, with parainfluenza virus type Ⅰ (Sendai) BB 1株attacks continue to take 5 d, a protective role in mice, the mice can significantly reduce Mortality [46]. Decoction of percent of their concentration. The Sindbis virus, Newcastle disease virus, follicular stomatitis virus and influenza viruses have antiviral activity [47]. (7), artemisinin: water suspension , , / embryo, the embryo infected with influenza virus A 3-Beijing Section 79 - two inhibit [48]. Agar plate method to test for Staphylococcus aureus, E. coli, streptococcus B, pneumococcal the LC 50 (mg / ml) of its decoction were , , ,> 200: ethanol extract of their respective To , , , ethanol extract of goods were , , , The drug acid on Staphylococcus aureus, Staphylococcus white, enterococci, Bacillus subtilis the minimum inhibitory concentration, respectively , ,> , [49]. The flooding of soft artesunate 1: 3 concentrations in vitro on XU Lan Huang's Xuanjun, Aodu Ang's small Bacillus Xuanjun, the star's card slaves Jundeng skin fungus, have different degrees of inhibition [50 ]. (8), Bajitian: ethanol extract, in vitro to inhibit Bacillus subtilis [51]. Bajitian ethanol extract of in vitro to inhibit the hepatitis B virus [52]. . The impact of the hematopoietic system (A), Astragalus: decoction of 20 g / kg, a total of 10 d, anemia and bleeding on acetylcholine PHENYLHYDRAZINE hemolytic anemia are caused by blood can increase the red blood cells and haemoglobin, cyclophosphamide caused by the WBC and platelet reduce Promote their recovery, would increase the number of reticulocyte and the number of bone marrow cells [53]. (2), Chinese wolfberry: normal mice monthly ig10% decoction of ml for 10 d, WBC will increase. Healthy people and cancer patients taking po wolfberry nuts 50 g / d, even serving 10 d, can significantly increase the WBC [54, 55]. LBP 10 mg / () ip, for 3 d, can promote mouse bone marrow hematopoietic stem cell proliferation, increased significantly tablets single progenitor cells, promote their differentiation to the tablets [56]. (C), Dodder: the suppression of cyclophosphamide tablets progenitor cells (CFU-D) to promote the growth of [57]. . Anti-Fatigue Effect (A), Wumei: dry goods can eliminate fatigue, citric acid in the body the energy conversion process is indispensable to the material, physical fatigue in the blood lactate divided into CO 2 and H 2 O and from in vitro, thereby preventing lactic acid and muscle Protein binding, to avoid cell and vascular sclerosis [58]. (2), Cistanche: water decoction of the pharmacological experiments conducted in vitro studies showed that the inhibition of rat liver homogenate LPO and the formation of strong anti-fatigue and anti-anoxia role [59]. Decoction of gavage Cistanche mice, mice can extend the time for swimming, sports load serum creatine kinase reduce the rate of increase, indicating the increase in physical goods is on the basis of its role in the anti-fatigue [60]. Conclusion: After the "antidote Vitamin Tablets," Shi Sanwei prescription medicines in the analysis, summarized the following five aspects of the effect: 1. Shiwei drugs on immune function, namely: Qingdai, Hedyotis diffusa, Scutellaria barbata, astragalus, Chinese wolfberry son, artesunate, soil Fuling, Cistanche, Dodder, Bajitian. 2. Bawei Chinese medicine against pathogenic microbes inhibit, namely: Mian Ma Guanzhong, Qingdai, Hedyotis diffusa, Scutellaria barbata, Wumei, astragalus, artesunate, Bajitian. 3. Liuwei drugs to kill leukemia cells, namely: Mian Ma Guanzhong, Qingdai, Hedyotis diffusa, Scutellaria barbata, Wumei, artesunate. 4. Shamisen Chinese medicine on hematopoietic function, namely: Astragalus, Chinese wolfberry son, Cuscuta. 5. The fight against drug taste of the role of fatigue are: Wu Mei, Cistanche. According to this analysis, for detoxification vitamin tablets provide further clinical application of the reference. 我给你一个英文药理文献网，里面有你说需的！：

Answer:"Pharmacy" is the English translation of"药学".

扩展知识

1.定义Definition

药学是研究药物发展、制备、质控、临床应用等方面的科学，旨在确保人类获得高质量、安全、有效的药物。

2.历史与发展History and Development

药学起源于古代中药学，经过千年发展，现已形成了包括药物化学、药剂学、药理学、毒理学在内的多个分支学科，在新药研发和制药生产等方面发挥着极其重要的作用。

3.药学专业Pharmacy Major

药学专业主要涉及到药物的质量控制、研发、管理、以及药房和医院药剂部门的管理等，培养了一大批专业人才，为社会医疗服务提供了坚实的人力后盾。

4.药品审批Drug Approval

药学在药品审批方面也具有重要作用，药品需要经过从研发到上市的多个环节的审批和监管，药学专业人才负责保证药品的安全性和有效性。

5.制药大国Pharmaceutical Power

中国是制药大国之一，药学专业人才的培养和创新对于中国药品工业的发展至关重要。同时，随着国际合作的加深，中国药品也开始向世界输出。

6.药学教育Pharmacy Education

药学教育则是培养药学专业人才的重要途径，包括本科、研究生等多个层次。不同学校和地区的药学教育存在差异，但都致力于培养具有专业知识和实践经验的人才。

7.未来发展Future Development

随着社会医疗需求和技术水平的发展，药学也将面临新的挑战和机遇。未来，药学将加强与其他学科的交叉合作，在新药研发和药品质量监管等方面持续创新。

【分享】有奖翻译外文文献摘要（药物专区） 药物专区 这篇综述重点阐述了藻类中具有食用和保健价值的各种长链不饱和脂肪酸的研究状况。 文题：Lipids and lipid metabolism in eukaryotic algae 作者：Guschina, I. A. Harwood, J. L. 杂志全名：Progress in Lipid Research 年份，卷（期）: 起止页码： 2006, Vol 45, No 2, 160-186 英文摘要： Eukaryotic algae are a very diverse group of organisms which inhabit a huge range of ecosystems from the Antarctic to deserts. They account for over half the primary productivity at the base of the food chain. In recent years studies on the lipid biochemistry of algae has shifted from experiments with a few model organisms to encompass a much larger number of, often unusual, algae. This has led to the discovery of new compounds, including major membrane components, as well as the elucidation of lipid signalling pathways. A major drive in recent research have been attempts to discover genes that code for expression of the various proteins involved in the production of very long-chain polyunsaturated fatty acids such as arachidonic, eicosapentaenoic and docosahexaenoic acids. Such work is described here together with information about how environmental factors, such as light, temperature or minerals, can change algal lipid metabolism and how adaptation may take place. 中文译文： 真核藻类中脂类及其代谢研究综述 真核藻类是一大类具有多样性的种群，它的覆盖范围很广的，栖息地遍及从南极圈到沙漠的各类生态系统。藻类占据了初级生产力的一半以上，成为食物链的基础。近年来，人们对藻细胞中脂类物质的生化研究已经从很少的几种模式微生物其他物种拓展，开展了对众多物种包括一些非常见藻类的研究。这些研究带来了许多新的化合物的发现，包括一些细胞膜的主要组分、以及脂类信号转导途径中的重要分子。这些研究的主要目标是寻找这些长链不饱和脂肪酸合成蛋白的编码基因。同时本文中还综述了环境因子（例如光、温度、微量元素）对藻类脂肪代谢的影响以及藻细胞的应答机制的相关研究信息。 影响因子（2005） -------------------------------------------------------------------------------- 全文连接 and lipid metabolism in eukaryotic () -------------------------------------------------------------------------------- 全文连接－2 and lipid metabolism in eukaryotic () -------------------------------------------------------------------------------- 共翻译了5篇，其中三篇综述，两篇研究性文章。都是有关海洋药物方面的，大部分是海洋抗癌药物。尽我所能进行了翻译，部分词汇查不到中文译名，就没有翻译。 个人认为第四篇文章的水平很高，这时发表在PNAS上面的文章，一般化学类的文章，JACS（影响因子7左右）是顶级的杂志了。做的是海洋复杂天然产物的构型构象确定，该化合物是一个含侧链的25元环的大环内酯。类似于沙海葵毒素，研究方法也是从结构的片断开始，逐步确定其立体结构，当然本文所研究的结构没有沙海葵毒素（由129个碳原子组成的聚醚化合物，分子量为2677，含有40个羟基和8个甲基）那么复杂。虽然本文没有确定整个结构的立体结构，但本文的研究为确定该类型化合物的立体结构打下了基础。 第一篇（文章类型：Review） 文题：Marine pharmacology in 2003–2004: Anti-tumour and cytotoxic compounds 作者：Alejandro . Mayer, Kirk R. Gustafson 杂志全名：European Journal of Cancer（IF for 2005：；IF for 2005：） 年份，卷（期）: 起止页码：42 (2006 )：2241－2270 英文摘要：During 2003 and 2004, marine pharmacology research directed towards the discovery and development of novel anti-tumour agents was published in 163 peer-reviewed articles. The purpose of this reviewis to present a structured assessment of the anti-tumour and cytotoxic properties of 150 marine natural products, many of which are novel compounds that belong to diverse structural classes, including polyketides, terpenes, steroids and peptides. The organisms yielding these bioactive marine compounds include invertebrate animals, algae, fungi and bacteria. Anti-tumour pharmacological studies were conducted with 31 structurally defined marine natural products in a number of experimental and clinical models that further defined their mechanisms of action. Particularly potent in vitro cytotoxicity data generated with murine and human tumour cell lines was reported for 119 novel marine chemicals with as yet undetermined mechanisms of action. Noteworthy is the fact that marine anti-cancer research was sustained by a global collaborative effort, involving researchers from Australia, Austria, Canada, China, Egypt, France, Germany, Italy, Japan, Mexico, the Netherlands, New Zealand, Papua New Guinea, the Philippines, South Africa, South Korea, Spain, Switzerland, Taiwan, Thailand and the United States of America (USA). Finally, this 2003–2004 overview of the marinepharmacology literature highlights the fact that the discovery of novel marine anti-tumour agents continued at the same pace as during 1998–2002. 中文译文(包括题目)： 2003-2004海洋药理学：抗肿瘤及细胞毒化合物 2003至2004年度，研究方向为寻找发现新抗肿瘤药物的海洋药理学论文总共发表了163篇。 本综述旨在对大约150个海洋天然产物的抗肿瘤及细胞毒活性进行化学结构上的分析，其中许多化合物属于不同的结构类型，包括聚酮化合物、帖类、甾体以及多肽。产生这些活性化合物的生物包括无脊椎动物、海藻、真菌和细菌。在大量的实验及临床模型上，研究人员对31个结构明确的海洋天然产物进行了抗肿瘤药理研究，这样的研究进一步明确了其作用机制。据报道，共有119种新的海洋化合物在体外对鼠或人类肿瘤细胞有特别强的细胞毒作用，作用机制尚未阐明。值得注意的是，全球许多国家合作进行海洋抗肿瘤药物研究，包括澳大利亚、奥地利、加拿大、埃及、法国、德国、意大利、日本、墨西哥、荷兰、新西兰、新几内亚、菲律宾、南非、南朝鲜、西班牙、瑞士、台湾、泰国及美国。最后，2003－2004年的海洋药理学研究综述表明发现新抗肿瘤化合物的速度与1998－2002期间一致。 第二篇（文章类型：Review） 文题：Indole alkaloid marine natural products: An established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases 作者：Waseem Gul, Mark T. Hamann 杂志全名：Life Sciences（IF for 2005：；IF for 2005：） 年份，卷（期）: 起止页码：78 (2005)：442－453 英文摘要：The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, antiinflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities. 中文译文(包括题目)： 吲哚生物碱海洋天然产物：明确的抗癌药物先导化合物库，在治疗寄生虫病、神经病及其它疾病具有良好的前景 海洋产生了大量的各种结构类型的天然产物，它们作用于不同的疾病靶点。历史上，对海洋天然产物的研究大都是在抗癌方向。海洋中的吲哚类生物碱在作为新药先导化合物方面，具有独一无二的良好前景。本文综述了有关海洋来源的吲哚生物碱的文献，同时也包括了我们自己的研究。在这里，我们展示了吲哚类生物碱的独特生物活性，包括：细胞毒、抗病毒、抗寄生虫、抗炎、拮抗5-羟色胺、钙释放、拮抗钙调蛋白及其他药理活性。 第三篇（文章类型：Review） 文题：Marine natural products as anticancer drugs 作者：T. Luke Simmons, Eric Andrianasolo, Kerry McPhail, Patricia Flatt, and William H. Gerwick 杂志全名：Molecular Cancer Therapeutics（IF for 2005：；IF for 2004：） 年份，卷（期）: 起止页码：2005;4(2)：333–42 英文摘要：The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs. 中文译文(包括题目)： 作为抗肿瘤药物的海洋天然产物 海洋环境的化学与生物多样性是无法衡量的，因此海洋是发现新抗癌药物的特别资源库。今年来，结构鉴定、有机合成、生物分析在技术及方法学方面的发展带动了各种新抗癌药物的分离及临床评价。这些化合物的结构各异，从简单的线性多肽如多拉司他汀10，到复杂的大环聚醚类化合物如软海绵素B。有如结构差异，这些化合物赖以传递作用的分子模式也各不相同。本文综述了一些来自海洋的天然产物及其合成衍生物，目前这些化合物正作为抗癌药进行临床评价。 第四篇（文章类型：research article） 文题：Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A 作者：Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, and Jonathan Stafford 杂志全名：proceedings of the national academy of sciences of the united states of america 年份，卷（期）: 起止页码：2004 August 17; 101(33): 11986–11991. 英文摘要：Reidispongiolide A is a representative member of the sphinxolide/reidispongiolide group of cytotoxic 26-membered macrolides of marine origin. By interacting with actin in the cell cytoskeleton, the reidispongiolides and sphinxolides are potent microfilament destabilizing agents that represent a promising mechanism of action for developing novel anticancer drugs. An aldol-based synthesis of a library of diastereomers of C8–C16 and C5–C16 fragments and detailed NMR comparison with a reported degradation fragment enabled a configurational assignment for a major part of the reidispongiolide macrocyclic core, thus setting a solid foundation for ongoing synthetic efforts. 中文译文(包括题目)： 具抗微丝活性的海洋大环内酯合成：reidispongiolide A分解片断C5–C16的合成及构象指定 Reidispongiolide A是来自海洋的含sphinxolide/reidispongiolide 基团的26元环大环内酯类化合物的代表。通过与细胞骨架的肌动蛋白相互作用，这些大环内酯类化合物使得微丝失稳，这是研发新抗癌药物的有望机制。从丁间醇醛开始，合成了C8-C16及C5–C16的非对映体库，并将其NMR数据与一已报道的分解片断进行详细的比较，从而指定了reidispongiolide大环母核主要部分的构象，为后续的合成工作提供了坚实的基础。 第五篇（文章类型：research article） 文题：Aureoverticillactam, a novel 22-atom macrocyclic lactam from the marine actinomycete Streptomyces aureoverticillatus. 作者：Scott S. Mitchell, Benjamin Nicholson, Sy Teisan, Kin S. Lam, and Barbara C. M. Potts 杂志全名：journal of natural products（IF for 2005：； IF for 2004：） 年份，卷（期）: 起止页码：2004 Aug;67:1400-2. 英文摘要：During the course of our screening program designed to discover novel anticancer and anti-infective agents from marine microorganisms, a strain of Streptomyces aureoverticillatus (NPS001583) isolated from a marine sediment was found to produce a novel macrocyclic lactam with cytotoxicity against various tumor cell lines. Using extensive MS, UV, and NMR spectral analyses, the structure has been established as compound 1, aureoverticillactam, a 22-atom macrocyclic lactam incorporating both triene and tetraene conjugated olefins. 中文译文(包括题目)： 由海洋放线菌Streptomyces aureoverticillatus产生的22元环大环内酰胺Aureoverticillactam 在试图从海洋微生物中筛选得到新抗癌药物的过程中，我们发现一株分离自海洋沉积物的链酶菌属放线菌aureoverticillatus (NPS001583) 能产生一种新的大环内酰胺，其对数种不同的肿瘤细胞都有细胞毒作用。运用包括质谱、紫外及核磁共振的多种光谱分析，解析确定了该化合物1（aureoverticillactam）的结构，是一个含有共轭三烯和共轭四烯的22元环大环内酰胺。 如果你英语水平可以的话，可以直接到 （美国专利网）找找。《外文文献信息检索》PPT版(包括：外文图书信息检索、外文期刊论文检索、外文报纸检索），如有需要再联系我。

原文31岁的药理药效上746-752学报中央(2010年六月)|往颇具声望二期临床试验的吉西他滨+顺铂患者在先进的非小细胞肺癌云的球迷,Neng-ming林,Sheng-lin马,Lu-hong咯,罗芳、Zhi-yu黄,Hai-feng禹和Feng-qin吴文摘目的:药效学和药代动力学研究的dFdC吉西他滨(d)日中在1个月和5 +顺铂日中在d阶段1患者希望加及第四期非小细胞肺癌(NSCLC)。方法:在每一种组合后的第一个周期,吉西他滨是一剂1250毫克/ m2作为一个30分钟静脉(四)灌注对d 1个月和5,紧随其后的是顺铂在一剂量的75毫克/ m2作为3小时iv灌注对d每个3个星期。(四)之间的两种浸剂1小时。临床治疗效果和毒性的方案进行了观察。此外,血浆浓度吉西他滨(dFdC)及其代谢产物(dFdU)不同时间点的检测在第一个循环的效果。药代动力学软件(战)是用来估计的药代动力学参数及其代谢产物的dFdU吉西他滨。结果:一共有28个病人被纳入本研究。人的平均年龄是54岁(范围27-75年),大多数病人在良好的临床状况。27例患者接受两种或两种以上的治疗周期。整体的临床反应率为。整体的生存时间的中位数是13个月。平均估计时间肿瘤进展(待)是个月,1年生存率率和。容忍的毒性作用。myelosuppression;主要毒性的3 / 4的患者有品位血液学毒性和级的3 / 4 non-hematologic毒性,胃肠道反应被普遍。药物代谢动力学参数和dFdU dFdC没有差异的售前和post-administration在d 1和5.吉西他滨是最小的dFdU±μg( /毫升)之前在d溶入吉西他滨是5,和吉西他滨是不存在。结论:该训练是活跃且耐受性良好的非小细胞肺癌患者在加先进。日中在d吉西他滨是后1个月和5、药代动力学参数的显示和dFdU dFdC前没有区别,dFdU输注前吉西他滨是最小日中在d是5。