医学英语文献选读5unit4

Wang, Zhe*,||; Huang, Gaosheng*,||; Yan, Qingguo*; Wang, Lu*; Zhu, Jin*; Lu, Yang*; Li, Peifeng*; Cheng, Hong*; Ma, M Joe?; Walker, Bruce F?; Allen, Philip W§AbstractAim: To describe two patients with a highly aggressive, apparently ‘new’ and rare soft tissue and bone malignancy of childhood and early adult life that we have named inflammatory monomorphic undifferentiated Methods and results: Two histologically identical tumours located in the proximal humerus and the anterior chest wall of males aged 6 and 31 presented as solitary, painful, tender, necrotising, masses, associated with fever, leukocytosis and negative microbiological The extensively necrotic resected tumours consisted of large, monomorphic epithelioid cells with vesicular nuclei, prominent eosinophilic nucleoli, and abundant eosinophilic cytoplasm surrounded by numerous neutrophils and eosinophils which formed sterile Immunohistochemical and ultrastructural studies revealed no specific Both tumours were very aggressive, with early local recurrence, metastasis to regional and distant lymph nodes and viscera, and no response to several different chemotherapeutic Conclusion: A careful review of the literature led us to believe that inflammatory monomorphic undifferentiated sarcoma may represent a rare and distinct clinicopathological entity that does not appear to have been previously describ 要给我(⊙o⊙)哦

5(GDF-5生长分化因子) GDF-5充当信号,为软骨形成, 成长,图案的发展脊椎动物 骨架。它被表达在发展interzone 关节。会员GDF-5转变的生长 因素TGF_ -科的信号分子) 参与关节软骨开发、维护、 与再生(34)。GDF-5促进骨软骨细胞 分化和刺激蛋白多糖的合成。 GDF5_ / _老鼠(brachypodism)制定 指间手腕和踝关节缺陷(34)。 天使形状的闹上体 气体动力设备5引起的突变 不典型增生的癌前期病变,其特点是影响食欲办公 髋部和手关节(遗传105835号)。个人 现在与身材矮小,多脑上体发育不良, 和缺牙。趾骨缩短中间 天使形状 脑上体的发育不全是相似的 观察

5(GDF-5生长分化因素)GDF-5充当信号,为chondrogenesis、成长的发展模式vertebrateskeleton。它被表达在发展interzone关节。会员GDF-5转化生长因子TGF_)-科的信号分子,参与关节软骨开发、维护、及再生(34)。GDF-5促进骨软骨细胞分化和刺激蛋白多糖合成GDF5_ / _老鼠(brachypodism指间建立手腕和踝关节缺陷(34)Mutations GDF5引起angel-shaped epiphyseal在办公具有发育不良,影响食欲臀部和手关节(遗传105835号)。个人现在与身材矮小,多epiphyseal发育障碍,hypodontia。在angel-shaped中间phalangeal缩短epiphyseal发育不全是类似于brachydactyly中观察到C,以及这个观察导致GDF5的识别这个实体的突变杂合的突变brachydactyly GDF5也会引起C类,其特点是短的中间第一趾骨逆行掌骨近端关节(35)。纯合子的GDF5突变导致的嘴上和Hunter-Thompson形式的acromesomelic骨骼dys - plasias、杜二盘不典型增生的癌前期病变(35)。多态性相GDF5的发起者(表3)也被认为对预测髋关节和膝关节骨性关节炎在亚洲人口结果的敏感性,降低了在transcriptionalactivity多态性chondrogenic细胞。Wnt-induced信号蛋白3(WISP-3)小精灵基因是家庭成员的成员在广东细胞生长分化与最初被发现有一种癌症中可能的作用(36)。Wnt信号调节软骨细胞表型、成熟、和功能。只有WISP3被视为伴随着人类疾病。WISP-3是synoviocytes分泌蛋白表达了和软骨细胞和人类是非常必要的软骨的完整性。WISP3隐性突变造成轻微的chondrodysplasia称为进步的pseudorheumatoid撕裂。hildhood(遗传208230号)。现在受到影响的个人年龄在3年,8年,进行性小型和大型联合polyarthritis、刚度,并减少机动性。没有临床证据的炎症。揭示了spondyloepiphyseal骨骼影像学特点,megaepiphyses发现:platyspondyly,以及扩展的两端趾骨射线巨型的示范操作系统trigonum能鉴别这个实体类风湿性关节炎。最近,多态性相已经被证明WISP3颁授对佳(表3)。一个特定的多形性Wnt拮抗剂,Frizzled-related蛋白质3,目前也被媒体作为OA易感基因的影响(表3)。