汤俊连发表的论文

研究兴趣与方向：中药及其活性成分的体内外代谢及PD/PK研究；天然产物（有毒成分）的化学药理学及毒理学研究；基于现代分析技术的生药鉴定与质量评价研究科研课题：1. 国家自然科学基金面上项目 2013.1-2016.12，项目负责人2. 武汉大学引进人才科研启动基金项目 2007.2-2010.2，项目负责人代表性论文（*：通讯作者）：[1] Zihao Zhou，Jun Tang*, Xueping Song. Chemical Composition of the Essential Oil of Ligularia hodgsonii and Free Radical Scavenging Activity of the Oil and Crude Extracts. Natural Product Communications 2014, 9(10): 1511-1514.[2] Ju-Xiu He*, Kenji Ohno, Jun Tang, Masao Hattori, Tadato Tani, Teruaki Akao. Da-Chaihu-Tang alters the pharmacokinetics of nifedipine in rats and a treatment regimen to avoid this. Journal of Pharmacy and Pharmacology. 2014, doi: 10.1111/jphp.12285.[3] Jun Tang*, Zhengtao Wang, Teruaki Akao, Masao Hattori. Further evidence on the intramolecular lactonization in rat liver microsomal metabolism of 12-O-acetylated retronecine-type pyrrolizidine alkaloids. Natural Product Communications 2013, 8(11): 1545-1546.[4] Min Cheng, Qigui Mo, Yun Xu, Jun Tang*. Quality evaluation of Arnebiae Radix using multiple qualitative and quantitative methods coupled with multivariate statistical analysis. Current Pharmaceutical Analysis 2013, 9: 217-225.[5] Jun Tang*, ZhengTao Wang, Teruaki Akao, Masao Hattori. Human intestinal bacteria mediate reduction of the N-oxides of isoline and monocrotaline to the corresponding parent alkaloids.Asian Journal of Chemistry 2013, 25(4): 2027-2030.[6] Jun Tang*, Min Cheng, Masao Hattori. Pyrrolizidine alkaloid profile in a traditional Chinese herbal medicine Chuan Zi Wan (Ligulariae Radix et Rhizoma) by liquid chromatography/electrospray ionization ion trap mass spectrometry. Analytical Methods 2012, 4: 2797-2808.[7] 汤俊*，服部征雄. 《中国药典》含吡咯里西啶生物碱的中药品种与用药安全. 药学学报 2011, 46(7) : 762-772.[8] Jun Tang, Yibin Feng, Saiwah Tsao, Ning Wang, Robert Curtain, Youwei Wang. Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations. Journal of Ethnopharmacology 2009, 126 (1): 5-17.[9] Jun Tang, Teruaki Akao, Norio Nakamura, Zhengtao Wang, Kiyoshi Takagawa, Masakiyo Sasahara, Masao Hattori. In vitro metabolism of isoline, a pyrrolizidine alkaloid fromLigularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors. Drug Metabolism and Disposition 2007, 35: 1832-1839.