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医学论文加翻译

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医学论文加翻译

医学论文翻译一般较多的是医学论文的摘要翻译,即把医学论文的摘要翻译成英文,在国外期刊上发表都会要求整篇论文翻译成英文。一、在相关专业医学论文翻译中,要达到表意准确,必须了解相关领域的知识,熟练掌握同一概念的中英文表达法。单纯靠对语言的把握也能传达双方的语言信息,但在运用语言的灵活性和准确性两方而部会受到很大限制。要解决这个问题,译者就要努力熟悉这个领域的相关知识,比如,因此了解相关领域知识,在翻译过程中对翻译人员的语言理解力和医学论文翻译质量都有很大帮助。二、医学论文翻译的翻译标准。医学论文翻译标准是翻译实践的准绳和衡量译文好坏的尺度。关于翻译的标准,历来提法很多。有的主张“信、达、雅”,有的主张“信、顺”等等。但有一点是共同的,即一切译文都应包括原文思想内容和译文语言形式这两方面。>为此,在进行医学论文翻译时应坚持两条标准:>(一)忠实。应忠实于原内容,准确地、完整地、科学地表达原文的内容不得有任何篡改、歪曲、遗漏或任意增删的现象。内容通常指文中所叙述的事实,说明的事理,作者在叙述、说明和描写过程中所反映的思想、观点、立场和所流露的感情等。>(二)通顺。医学论文翻译语言必须通顺易懂,符合规范,用词造句应符合本族语的习惯,要用民族的、科学的、大众的语言,以求通顺易懂。不应有文理不通、结构混乱、逐词死译和生硬晦涩等现象。三、过程中要体现语言结构特色(一)词汇上的特点1. 词义演变。医学论文翻译的专业词汇通常都出现在特定领域,它一般分为两类:一类是某一专业特有的词汇,这类词汇一般具有一词对应一义的特点;还有一类由普通词汇演变而来的专业词汇,这类词汇一词多义,必须应用语言学知识和专业知识综合分析,在翻译实践中不断丰富扩大。2. 词缀。比如:从词源学的角度来看,在医学英语词汇中,希腊语、拉丁语的词素占有极高比率。据Oscar 的统计,一万个医学词汇约有46%来自拉丁语;来自希腊语,希腊、拉丁词素是医学英语词汇的重要基础。希腊语、拉丁语拥有极丰富的词缀,且每个词缀都有其固定意义,可与不同的词干组成无数新词。3. 动词多使用规范的书面语。英语词汇从语体的特点来分,可分为普通词汇和正式词汇。普通词汇大部分是英语本族语,常用于英语口语和文学作品中,正式词汇大部分是外来词,常用于科技、经济、政治等较正式的文章中。(二)大量使用名词化结构1. 医学论文中大量使用名词化结构 (Nominalization)是医学论文翻译的特点之一,因为文体要求行文简洁、表达客观、内容确切、信息量大、强调存在的事实,而非某一行为。2. 大量使用长句和定语从句医学论文翻译中大量使用长句和定语从句,在论证上起到连接信息和强调信息的作用。3. 名词作定语和缩写词使用频繁。医学论文翻译中要求行文简炼、结构紧凑,名词作定语和缩写词的频繁使用,简化了句型,增大了信息密度。4. 广泛使用被动语态。医学论文中侧重叙事推理,强调客观准确,第一、二人称使用过多,会造成主观臆断的印象。因此尽量使用第三人称叙述,采用被动语态。四、医学论义翻译的翻译方法。医学论义翻译要提高翻译量,使译文达到准确、通顺这两个标准,就必须运用医学论文翻译技巧。医学论文翻译技巧指翻译过程中用词造句的处理方法,如词义的引申、增减、词类转换和领域术语的翻译方法等。(一)引申法。医学论文翻译时,有时会遇到某些词在英语词典上找不到适当的词义,如果任意硬套或逐词死译,会使医学论文翻译生硬晦涩,不能确切表达原意,甚至造成误解。这时则可以在不脱离该英语词义的前提下,灵活选择怡当的汉语词语或词组译出。(二)增词译。由于英汉两种语言在词语用法、句子结构和表达方式上有许多差异,医学论文翻译时往往需要增加一些原文中没有的词,使译文通顺而且更加忠实地表达原文的意思。增词译的情况有两种。一种是根据意义或修辞的需要,如增加表示时态意义的词,增加英语不及物动词隐含的宾语意义的词。另一种是根据句法上的需要,增加原文句子中所省略的词。(三)省略译。省略译是将原文中的宥些词省略不译,以使译文符合语言习惯。(四)词类转换英译汉时,常常需要将英语句子中属于某种词类的词,译成另一种词类的汉语词,以使译文通顺自然,符合汉语的表达习惯。这种翻译处理方法就是转换词性法,简称词类转换。(五)领域专业术语的译法。医学论文翻译中有大量的术语,而且科学性、专业性很强。领域专业术语的译法有意译、音译、象形译和原形译四种。总之,医学论文的翻译需要专业的医学学科知识和大量对学术名词的积累。希望能帮到你,也可以自己去找相关的机构帮你

这个需要专业的翻译才能搞定,需要的话可以联系我。

我当时没办法解决,英文不好,找的清北医学翻译。医学翻译的第一。非常好。

翻译软件仅供参考,不能过分依赖,想要高质量的翻译还是需要专业的翻译人士和平台,个人还是比较信赖北京译顶科技

医学论文翻译器加盟

淘宝上有很多翻译的店,可以找评价比较好的店。翻之前可以让店家试译一下。

医学论文翻译肯定得找清北医学翻译,他们是这块的领军翻译公司,行业里的翘楚,质量名不虚传,你试试就知道有多好了

艾德思可以做这个。

毛遂自荐一下,译国译民翻译集团,我们集团提供的翻译服务:

医学文献翻译:服务范围涉及一次文献:医学论文 (论著)、医学报告、临床报告;二次文献:书目、题录、简介、文摘;三次文献:医学情报、综述、述评等。为客户提供灵活多样的翻译服务方案,多层次满足客户不同的翻译质量要求。医学论文润色:发表级服务包括人工翻译,语言专家审校、润色,译后排版服务和资深质检员质检。母语级服务包括人工翻译、审校,母语级润色、译后排版服务,资深质检员质检和整稿复看。

集团资质介绍:

译国译民集团成立于2003年,总注册资本超5000万元,多年专注翻译服务领域,在全国布局,相继成立了16家公司,拥有译国译民、一生译事、翻译米、匡网、诺贝笔、联国、译道、译语国际等众多子品牌。是中国翻译协会理事单位和美国翻译协会会员单位,是中国领先的专业翻译公司之一,服务对象涵盖世界500强企业在内的超5万家企业客户。

2017年被国际权威机构CSA评定为全球百强语言服务商(全球排名第74)。深耕医学领域近二十年,处理经验累计超100亿字,我们始终不忘初心,致力于打造中国领先的医学翻译品牌,择一事,终一生,为客户提供最优质的语言翻译服务。

译国译民集团拥有专业的医学文献翻译组,主攻翻译,近20年行业经验,翻译质量更有保障;企业客户合作多,各类医学稿件均有钻研,十分了解医学研究情况;业务人员直接对接,以客户为中心,具有人文关怀。专而精,只做医学类论文翻译,一个领域做到极致。

英国医学论文加翻译

s why more and more people are being active in various kinds of sports and exercises.

If people follow these three ways of keeping fit. Some practice shadowboxing and swordplay while others run. Every morning many people get up early and take much exercise.

First, block the flow of blood, and therefore should be given up, walk or dance to music. This strengthens the heart. They advise people to eat more fruit and vegetables and less meat such as beef and pork because meat contains more fat than poultry and fish.

Medical researchers have proved that what people eat affects their health, it is essential to do the following. Some play basketball or volleyball or table tennis? Different people may give different answers to this question. Unfortunately few people follow this advice. Through sports and exercise, people bee healthier and stronger;s health a great deal. Smoking and drinking alcohol injure one'. Fat can build up in the arteries. That'.

Getting rid of bad habits like *** oking and drinking alcohol is also an important way to keep healthy, reduces the chance of heart attack. Research shows that getting plenty of exercise make the heart beat faster and the lungs work harder. In my opinion, it is absolutely necessary to take some exercise every day, and cause a heart attack or stroke. In the afternoon, others go in for gymnastics or track events,there are also many people keen on sports, and helps lower blood pressureHow to Keep Healthy

Nowadays more and more people are concerned about their health. But how to keep healthy, they greatly improve their health, jog

All people in urban and rural areas will enjoy basic medical care and health services by increasing government responsibility and spending, we will also encourage greater participation of private capital from both home and abroad in the reform covers a wide range of subjects including insurance, drug manufacturing, distribution and supervision, and legislation of medical put into place basic medical and health care systems covering both urban and rural residents, and ensure that every resident has access to safe。

The disturbing phenomenon has caused wide social concern. There are several underlying causes behind it. Nowadays, people tend to care more about their health and expect a longer life span, thus causing a boom in medical treatment. People are willing to spend more money on health care. Some hospitals take advantage of this and offer patients more unnecessary physical examinations in order to make more profits. 令人不安的现象引起了广泛的社会关注。

有几个背后的原因。如今,人们更关心他们的健康,期望寿命更长,从而导致了医疗的繁荣。

人们愿意花更多的钱在医疗保健上。一些医院利用这一优势,为患者提供更多不必要的体检,以使更多的利润。

In my view, it's high time that urgent measures should be taken to improve the present situation. First, doctors should live up to patients' expectations and put saving people's lives above anything else. Second, the authorities should shoulder its responsibility to ensure that hospitals provide people with high-quality medical care at a reasonable price. 在我看来,现在应该采取紧急措施来改善目前的形势了。首先,医生应该对病人的期望值,并把人的生命放在其他任何东西上面。

其次,当局应承担起它的责任,确保医院为人民提供高质量的医疗服务,以合理的价格。

The disturbing phenomenon has caused wide social concern. There are several underlying causes behind it. Nowadays, people tend to care more about their health and expect a longer life span, thus causing a boom in medical treatment. People are willing to spend more money on health care. Some hospitals take advantage of this and offer patients more unnecessary physical examinations in order to make more profits.

令人不安的现象引起了广泛的社会关注。有几个背后的原因。如今,人们更关心他们的健康,期望寿命更长,从而导致了医疗的繁荣。人们愿意花更多的钱在医疗保健上。一些医院利用这一优势,为患者提供更多不必要的体检,以使更多的利润。

In my view, it's high time that urgent measures should be taken to improve the present situation. First, doctors should live up to patients' expectations and put saving people's lives above anything else. Second, the authorities should shoulder its responsibility to ensure that hospitals provide people with high-quality medical care at a reasonable price.

在我看来,现在应该采取紧急措施来改善目前的形势了。首先,医生应该对病人的期望值,并把人的生命放在其他任何东西上面。其次,当局应承担起它的责任,确保医院为人民提供高质量的医疗服务,以合理的价格。

Campus Life 有关校园生活的英语作文

Early in senior high school, we longed to be enrolled in a university. Now the dream has e true. But how do we college students like our campus life?

Certainly, some relish it, finding it colorful and rewarding. Besides study, they spend considerable amount of time improving themselves in various aspect. Yet others do not think much of their college life, thus do not benefit as much. In their eyes, the university is just a bigger high school. The only difference is that they have more time at their disposal without parents looking over their shoulder.

As to me, college life is ideal if only I have abundant books to read, some bosom friends to keep me pany, a couple of conscientious professors to instruct me, and an easy access to the Inter.

范文二:

My station in university campus inch territory, breathes and feels a here freshness. The university life like this started. The life four years time already the picture got down certainly has run the line, you along this path endless long journey, the university time will say regarding me will be fresh, the biography first time was far away the hometown, trod studies the road. I to the university life am fuzzy, after investigates many times, everybody is o characters ----- is bored to the university life feeling, perhaps has that a reason! Three years high school life is such intense stimulates. Recollected also a little is afraid, facing high school's intense sprint, diligently was admitted to a school dream of the university, everybody is the like this struggle, assaults the dream. At the present, steps into the university campus, studies the life has had the bored feeling.

DESIGN AND IMPLEMENTATION OF PRODUCTION PLANNING MANAGEMENT SYSTEM OF SURVEYING AND MAPPING PROJECTKEY WORDS: GIS,Design,Analysis,Application,Management,ProductionABSTRACT:With the development of photogrammetry and spatial information sciences, we have found many new methods to solve the technical problem in surveying and mapping project. But there is a little research on the project management. Traditional management method is plex and time-consuming. Now, we need use new technique to improve the management method for enhancing management level. Taking “National Western Surveying and Mapping Project on 1:50000 Topological Maps Blank Area” as an example, this paper focus on production planning management. The project is remarkable, not only the task and extent is tremendous, but also the staff and stuff are excessive. The Blank Area has atrocious weather and extreme hypsography. All of the conditions increase the project management difficulty. For reasonable planning and logical budget, we designed and realized a production planning management system to give the decision support to the managers. This paper studies the system'e69da5e6ba903233363533362s requirement *** ysis, system structure and function in . INTRODUCTIONNowadays, Geographical Information Systems(GIS) are powerful and useful as means of information, visualization and research tools(Quan Bao,2004). Most GIS sofare is more suited to providing limited types of output than as a tool to support, at anything other than a superficial level, tactical or strategic decision-making processes. To improve the usefulness of GIS as a decision support tool, o needs are apparent. First, decision-makers require methods that allow them to easily select alternatives across a number of relevant criteria. Second, it is necessary to explicitly recognize that most decision-making processes involve multiple participants. Since problem solving id often characterized by multiple and conflicting objectives, methods that contribute toward more a pletely aiding decision system are required.。

你可以去创新医学网上看看,而且还有翻译服务。

这种比较专业性的好的免费的论文在网上很难找,就算找的应该也不是完整的,特别是免费的,建议你去学校图书馆阅览室,你不有阅览证吗?那里很多,选择性多呀,含金量也比较高.

去PubMed检索,列表后面有fulltext提示,部分新发布的论文免费提供全文。旧刊全文收费不便宜,一篇几美金到20多美金不等。

医学论文翻译公司加盟

艾德思可以做这个。

毛遂自荐一下,译国译民翻译集团,我们集团提供的翻译服务:

医学文献翻译:服务范围涉及一次文献:医学论文 (论著)、医学报告、临床报告;二次文献:书目、题录、简介、文摘;三次文献:医学情报、综述、述评等。为客户提供灵活多样的翻译服务方案,多层次满足客户不同的翻译质量要求。医学论文润色:发表级服务包括人工翻译,语言专家审校、润色,译后排版服务和资深质检员质检。母语级服务包括人工翻译、审校,母语级润色、译后排版服务,资深质检员质检和整稿复看。

集团资质介绍:

译国译民集团成立于2003年,总注册资本超5000万元,多年专注翻译服务领域,在全国布局,相继成立了16家公司,拥有译国译民、一生译事、翻译米、匡网、诺贝笔、联国、译道、译语国际等众多子品牌。是中国翻译协会理事单位和美国翻译协会会员单位,是中国领先的专业翻译公司之一,服务对象涵盖世界500强企业在内的超5万家企业客户。

2017年被国际权威机构CSA评定为全球百强语言服务商(全球排名第74)。深耕医学领域近二十年,处理经验累计超100亿字,我们始终不忘初心,致力于打造中国领先的医学翻译品牌,择一事,终一生,为客户提供最优质的语言翻译服务。

译国译民集团拥有专业的医学文献翻译组,主攻翻译,近20年行业经验,翻译质量更有保障;企业客户合作多,各类医学稿件均有钻研,十分了解医学研究情况;业务人员直接对接,以客户为中心,具有人文关怀。专而精,只做医学类论文翻译,一个领域做到极致。

良好的商业技能。 如果您选择成为自由职业的医疗翻译或开办自己的医学材料翻译公司,您必须拥有一般商业技能,以便成功管理您的职业和财务。您必须了解如何设置专业费率,如何为客户计费,如何管理记录以及如何推销您的服务。集中精力。 您需要有能力专注于作业。你在做工作时不应该分心。医疗翻译是敏感的工作,需要高度的准确性。一个错误的词或术语可能会造成很大的损害,并使生命处于危险之中。对文化差异的敏感度。 其他文化有不同的期望和理解水平。你应该知道在不同的语言中使用哪些词汇和术语,这些词汇和术语会使你翻译的信息非常清晰,简单和易于理解。良好的人际交往能力。 如果您是自雇人士,您应该能够与雇用您服务的人员和公司建立良好关系,以留住客户,吸引新业务并拓宽您的网络。优秀的阅读和写作技巧。 您必须能够使用您正在使用的语言阅读您的翻译。同样,你必须能够有效,清楚地用目标语言书写。医疗翻译是一项令人兴奋但非常艰巨的工作。你的所有技能,才能和知识都应该高度配合。你将要翻译的许多文件都是由专家撰写的,并且意味着要由专家阅读,因此你必须是一位优秀的主题专家。虽然您可能具有在医疗行业工作的经验,但医学翻译所需的大部分技能将通过自学开发。否则,您可以参加医学翻译课程并获得证书。

你好,英语翻译公司还是有很多的,但是因为是医学文献的相关,所以还是找专业的医学翻译公司比较好,而且最好是有相关的医学翻译经验。这样才能保证你的资料翻译的标准和符合医学规范。彼岸译云翻译是专业翻译医学资料的公司,累积了很多的经验,可以帮助到你。建议可以将部分资料发给翻译公司的客服进行查看⌄然后评估翻译的难易度。

药学专业英语论文加翻译

Oral Administration 口服给药 For oral administration, the most common route, absorption refers to the transport of drugs across membranes of the epithelial cells in the GI tract. Absorption after oral administration is confounded by differences in luminal pH along the GI tract, surface area per luminal volume, blood perfusion, the presence of bile and mucus, and the nature of epithelial membranes. Acids are absorbed faster in the intestine than in the stomach, apparently contradicting the hypothesis that un-ionized drug more readily crosses membranes. However, the apparent contradiction is explained by the larger surface area and greater permeability of the membranes in the small intestine. 口服是最常用的给药途径,其吸收涉及药物通过胃肠道上皮细胞膜的转运。由于给药时相关环境条件的不同,如胃肠道管腔内pH及单位腔道容积的表面积,组织血流灌注情况,胆汁和粘液的存在以及上皮细胞膜的性质等,口服给药的吸收也有差异。酸性药物在肠中的吸收较胃中快,这显然与非解离药物更易透过细胞膜这一假设相矛盾。然而,这种明显的矛盾却可以从小肠具有很大的表面积和小肠细胞膜具有较大的通透性中得到答案。 The oral mucosa has a thin epithelium and a rich vascularity that favors absorption, but contact is usually too brief, even for drugs in solution, for appreciable absorption to occur. A drug placed between the gums and cheek (buccal administration) or under the tongue (sublingual administration) is retained longer so that absorption is more complete. 口腔粘膜上皮很薄,血管丰富,有利于药物吸收。但是,接触的时间太短暂,即使是溶液剂也来不及等到明显的吸收发生。把一种药物置于齿龈和面颊之间(颊部给药)或置于舌下(舌下给药)则可保留较长时间,使吸收更加完全。 The stomach has a relatively large epithelial surface, but because it has a thick mucous layer and the time that the drug remains there is usually relatively short, absorption is limited. Absorption of virtually all drugs is faster from the small intestine than from the stomach. Therefore, gastric emptying is the rate-limiting step. Food, especially fatty foods, slows gastric emptying (and the rate of drug absorption), explaining why some drugs should be taken on an empty stomach when a rapid onset of action is desired. Food may enhance the extent of absorption for poorly soluble drugs (eg, griseofulvin), reduce it for drugs degraded in the stomach (eg, penicillin G), or have little or no effect. Drugs that affect gastric emptying (eg, parasympatholytic drugs) affect the absorption rate of other drugs. 胃具有相对大的上皮表面,但由于它有较厚的粘液层,而且药物在胃内停留的时间相对较短,吸收也较少。事实上,所有药物在小肠中的吸收速度都要比胃中快。因此,胃排空即是一限速性步骤。食物,特别是脂类食物,延缓胃排空速度(从而也延缓药物吸收速度),这也就是为何某些希望迅速奏效的药物宜空腹服用的原因。食物可增强某些溶解性差的药物(如灰黄霉素)的吸收,减少胃内降解药物(如青霉素G)的吸收,食物以裁缝折吸收或无影响,或影响甚少。影响胃排空的药物(如副交感神经阻断剂)可影响其他药物的吸收速度。 The small intestine has the largest surface area for drug absorption in the GI tract. The intraluminal pH is 4 to 5 in the duodenum but becomes progressively more alkaline, approaching 8 in the lower ileum. GI microflora may inactivate certain drugs, reducing their absorption. Decreased blood flow (eg, in shock) may lower the concentration gradient across the intestinal mucosa and decrease absorption by passive diffusion. (Decreased peripheral blood flow also alters drug distribution and metabolism.) 小肠在胃肠道中具有最大的药物吸收表面积。十二脂肠腔内pH值为4~5,管腔内pH值趋碱性逐渐增强,至回肠下部时pH接近8。胃肠道内的菌丛可使某些药物失活,降低药物的吸收。血流量的减少(如休克病人)可以降低跨肠粘膜的浓度梯度,从而减少被动扩散吸收。(外周血流减少也会改变药物的分布和代谢。 Intestinal transit time can influence drug absorption, particularly for drugs that are absorbed by active transport (eg, B vitamins), that dissolve slowly (eg, griseofulvin), or that are too polar (ie, poorly lipid-soluble) to cross membranes readily (eg, many antibiotics). For such drugs, transit may be too rapid for absorption to be complete. 肠道通过时间肠道通过时间能影响药物吸收,特别是经主动转运吸收的药物(如维生素B)、溶解缓慢的药物(如灰黄霉素),或极性太高(即脂溶性差)难以透过细胞膜的药物(如许多抗生素)。这类药物通过太快,致使吸收不全。 For controlled-release dosage forms, absorption may occur primarily in the large intestine, particularly when drug release continues for > 6 h, the time for transit to the large intestine. 对控释剂型来说,吸收主要在大肠内进行,特别是药物释放时间超过6小时,也就是药物运达大肠的时间。 Absorption from solution: A drug given orally in solution is subjected to numerous GI secretions and, to be absorbed, must survive encounters with low pH and potentially degrading enzymes. Usually, even if a drug is stable in the enteral environment, little of it remains to pass into the large intestine. Drugs with low lipophilicity (ie, low membrane permeability), such as aminoglycosides, are absorbed slowly from solution in the stomach and small intestine; for such drugs, absorption in the large intestine is expected to be even slower because the surface area is smaller. Consequently, these drugs are not candidates for controlled release. 溶液剂型的吸收药物吸收受到大量胃肠道内分泌液的影响。药物要想被吸收,就必须要在与低pH环境及潜在的降解酶的接触中生存下来。通常,即使某种药物在肠环境中很稳定,但进入大肠的仍然是极少数。低亲脂性(即膜通透性低)药物,如氨基糖苷类,经胃和小肠溶液被缓慢吸收。而在大肠中,因表面积更小,预期吸收更慢。因此,这些药物不宜制成控释剂型。 Absorption from solid forms: Most drugs are given orally as tablets or capsules primarily for convenience, economy, stability, and patient acceptance. These products must disintegrate and dissolve before absorption can occur. Disintegration greatly increases the drug's surface area in contact with GI fluids, thereby promoting drug dissolution and absorption. Disintegrants and other excipients (eg, diluents, lubricants, surfactants, binders, dispersants) are often added during manufacture to facilitate these processes. Surfactants increase the dissolution rate by increasing the wetability, solubility, and dispersibility of the drug. Disintegration of solid forms may be retarded by excessive pressure applied during the tableting procedure or by special coatings applied to protect the tablet from the digestive processes of the gut. Hydrophobic lubricants (eg, magnesium stearate) may bind to the active drug and reduce its bioavailability. 固体剂型的吸收主要是出于方便、经济、药物稳定性、及病人接受性的考虑,大多数药物都以片剂或胶囊剂口服给药。这些制剂必须经过崩解和溶解才能被吸收。崩解大大增加了药物与胃肠液的接触表面积,从而促进药物的溶解和吸收。在制药过程中,为了促进崩解和溶解作用,往往添加一些崩解剂和其他赋形剂(如稀释剂、润滑剂、表面活性剂、粘合剂、分散剂)。表面活性剂通过增加药物的吸湿性、溶解度和分散性来增加其溶解速率。在制片过程中压片压力过大,或为了使药片免受肠道消化作用的影响而使用特殊的包衣,可延缓固体剂型的崩解。忌水性润滑剂(如硬脂酸镁)可与活性药物结合而降低其生物利用度。 Dissolution rate determines the availability of the drug for absorption. When slower than absorption, dissolution becomes the rate-limiting step. Overall absorption can be controlled by manipulating the formulation. For example, reducing the particle size increases the drug's surface area, thus increasing the rate and extent of GI absorption of a drug whose absorption is normally limited by slow dissolution. Dissolution rate is affected by whether the drug is in salt, crystal, or hydrate form. The Na salts of weak acids (eg, barbiturates, salicylates) dissolve faster than their corresponding free acids regardless of the pH of the medium. Certain drugs are polymorphic, existing in amorphous or various crystalline forms. Chloramphenicol palmitate has two forms, but only one sufficiently dissolves and is absorbed to be clinically useful. A hydrate is formed when one or more water molecules combine with a drug molecule in crystal form. The solubility of such a solvate may markedly differ from the nonsolvated form; eg, anhydrous ampicillin has a greater rate of dissolution and absorption than its corresponding trihydrate. 溶解速率溶解速率决定药物吸收时的可用度。当溶解速率低于吸收速率时,溶解就会制约吸收。药物的总体吸收可通过改变配方来加以调控,例如,减小颗粒体积可增加药物的表面积,从而增加那些溶解缓慢吸收受限的药物的胃肠道吸收速率和分量。药物的不同形式,如盐、晶体或水合物等,都可影响溶解速率。不管介质的pH是多少,弱酸的钠盐(如巴比妥酸盐,水杨酸盐)比其相应的游离酸溶解得快。某些药物有多种形态,可以非晶体形或不同晶体形存在。棕榈酸氯霉素有两种存在形态,但只有一种形态能充分溶解吸收,也因而被临床使用。当一个或多个水分子和一个晶体形药物分子相结合时,就构成一种水合物。这种的溶解度可能与非水合物的溶解度有明显的不同。例如,无水氨苄西林的溶解速率和吸收比其它相应水合物的溶解吸收速率都要快得多。

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Surfactants may affect drug dissolution in an unpredictable fashion. Low concentrations of surfactants lower the surface tension and increase the rate of drug dissolution, whereas higher concentrations of surfactants tend to form micelles with the drug and thus decrease the dissolution rate.表面活性剂可以影响药物溶出是一种不可预测的方式,低浓度的表面活性剂降低表面张力和提高溶出率,然而高浓度的表面活性剂趋于与药物形成胶团,因此降低药物溶出速率。Introduction of Nucleic acidsNucleic acids are polyanionic molecules of high molecular weight. These polymers are composed of sequence of subunits or nucleotides so that the whole is usually termed a polynucleotide. The nucleic acids are of two main varieties, ribonucleic (RNA) and deoxyribonucleic (DNA). DNA is found primarily in the chromatin to the cell nucleus, whereas 90% of RNA is present in the cell cytoplasm and 10% in the nucleolus. The two classes of nucleic acids are distinguished primary on basis of the five-carbon atom sugar of pentose present. Two general kinds of bases are found in all nucleic acids. One type is a derivative of the parent compound purine. Principle examples are guanine and adenine. The second class of bases found in all nucleic acid is derived from the parent compound pyrimidine. 介绍核酸核酸是超高分子量聚阴离子分子。这些聚合物组成,亚基或核苷酸,使整个通常称为多核苷酸序列。核酸有两种,主要品种核糖核酸(RNA)和脱氧核糖核酸(DNA)的。 DNA是主要存在于细胞核内的染色质,而90%的RNA在细胞质现在和10%的核仁。核酸类的两个主要的区别在于对目前的五个戊糖碳原子的糖基础。一般两个种基地发现,在所有核酸。一类是母体化合物嘌呤的衍生物。原理是鸟嘌呤和腺嘌呤的例子。在所有发现核酸碱基第二类是来自母体化合物嘧啶。

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