女性前列癌论文

据央视新闻报道，北京时间7月9日凌晨，美国加利福尼亚大学洛杉矶分校(UCLA)副教授吴梦婷获得美国国家科学院年度科学家奖(MNP Grimes),这是该奖项设立以来，首位中国女性获奖者。奖金100万美元，以表彰其在该领域的杰出贡献。获奖人吴梦婷获得一项新的科学成就。据介绍，获奖理由为“她是在利用 DNA序列鉴定疾病机制上做出贡献的女性”。

这些论文主要研究了什么？与我们生活息息相关呢？目前已知的三种肿瘤类型分别为：前列腺癌、乳腺癌）、肺癌。这是因为它们都与人体中的 DNA被翻译后发生改变从而导致疾病。但最近的研究发现：癌症的病理机制仍然不清楚，因为它们会“沉默”。此外，癌症和遗传也有关系。”吴梦婷介绍说，她做过研究发现细胞对人体非常重要。

细胞是由多种类型的细胞组成的，在分化过程中，不同模式的细胞会形成不同样子的膜结构、核质结构和功能，也会发生形态和其他变化。例如干细胞会有一些不一样的形态，有的可以是单核一样多细胞也有多个细胞核。当身体出现问题的时候，肿瘤就会生长。吴梦婷说：“因为你把它想象成一棵树没有叶子、没有花骨朵和果实的样子。

因为在这种环境下不可能长出任何一棵树和树木来帮助生长或为你治病，所以它会影响什么。但现在有一个奇怪的现象，因为每个人的身体中都存在不同大小的细胞，它们共同组成了一个生态系统。如果有错误，那么健康就会受到影响：例如吸烟会影响到肺功能以及心血管系统等等。”从一开始她就意识到需要多个方面保护细胞，它们才能维持正常发育等各个方面。。这是一个细胞分化过程中发生一些改变的问题。

伙计，看看这个行不？

:张立国、石建党、冯剑利、李钟、张琚. Type IV collagenase (matrix metalloproteinase-2 and-9) in prostate cancer. PROSTATE CANCER AND PROSTATIC DISEASES 吴荃，周颖，陈林峰，石建党，王春雨，苗琳，Mocker, H; Park, I;李钟，张琚. Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase expression in prostatic stromal cells via prostaglandin E2. JOURNAL OF ENDOCRINOLOGY王春雨，石建党，闫春和，吴荃，Klocker, H; Park, I;李钟，张琚. Development of a cell-isolation method for human prostatic smooth muscle cells based on cell type-specific activation of the SM22 gene promoter. BJU INTERNATIONALZhang, J; Qi, HX; Wang, HJ; Hu, P; Ou, LL; Guo, SH; Li, J; Che, YZ;Yu,YT; Kong, DL. Engineering of vascular grafts with genetically modified bone marrow mesenchymal stem cells on poly (propylene carbonate) graft. ARTIFICIAL ORGANS张智松王亮梅玫朱彦杜小玲李钟Irwin Park张琚石建党. Both nongenomic and genomic effects are involved in estradiol’s enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells. The Prostate樊官伟高秀梅王宏朱彦张琚胡黎明Yan-Fang Su, Li-Yuan Kang,张伯礼. The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estr. Journal of Steroid Biochemistry & Molecular Biology周颖肖向茜陈林锋杨睿石建党杜小玲Helmut Klocker, Irwin Park李钟张琚. Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats. Asian Journal of AndrologyIrwin I Park, Qiang Zhang, Victoria Liu,张琚, Chung Lee. Estrogen at low concentrations acts through distinct pathways in normal versus BPH-derived prostate stromal cells. the Journal of Clinical Endocrinology张立国王春雨杨睿石建党符蓉陈林锋Helmut Klocker张琚. Real-time quantitative RT-PCR assay of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood for detection of prostate cancer micrometastasis. Urol Oncol张智松段磊杜小玲马洪顺Irwin Park李钟张琚石建党. The proliferative effect of estradiol on human prostate stromal cells is mediated through activation of ERK. The Prostate吴荃石建党陈林锋王春雨Irwin Park李钟张琚. Regulation of proliferation and differentiation of prostatic stromal cells by estradiol through prostateic epithelial cells (BPH-1) in a paracrine manner. The BJU International刘树业Yu XD, Song CJ, Lu W, Zhang JD, Shi XR, Duan Y张琚. Cloning and expression of special F protein from human liver. World Journal of Gastroenterology牛远杰马腾骧张琚徐勇韩瑞发孙光. Androgen and prostatic stroma. ChinaAsian J AndrolZhou W, Park I, Pins M, Kozlowski JM, Jovanovic B,张琚,李钟, Ilio K. Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-beta1. Endocrinology张琚Klaus Jung, Michael Lein, Glen Kristiansen, Birgit Rudolph, Steffen Hauptmann, Dietmar Schnorr, Stefan A. Loening, and Ralf Lichtenhagen. Differential expression of matrix metalloproteinases and their tissue inhibitors in human primary cultured prostatic cells and malignant prostate cell lines. The Prostate牛远杰徐勇张琚马腾骧. Proliferation and differentiation of prostatic stromal cells. BJU InternationalSimone T. Boesch, Stefan Corvin,张琚, Hermann Rogatsch, George Bartsch, and Helmut Klocker. Modulation of the Differentiation Status of Cultured Prostatic Smooth Muscle Cells by an a1-Adrenergic Receptor Antagonist. The ProstateFibroblast Growth Factor Levels in Cancer Cell and in Sera of Patients suffering from Proliferative Disorders of the Prostate. The Prostate 张琚, Michael W. Hess, Martin Thurnher, Alfred Hobisch, Christian Radmayr, Marcus V. Cronauer, Anton Hittmair, Zoran Culig, Georg Bartsch and Helmut Klocker. Human prostatic smooth muscle Cell in culture: Estradiol enhances expression of smooth muscle cell-specific markers. The prostateZoran culig, Alfred hobisch, Marcus V. Cronauer, Christian Radmayr, Anton Hittmair,张琚, Martin Thurnher, Georg Bartsch and Helmut Klocker. Regulation of prostatic growth and function by peptide growth factors. The prostateMathias ziegler, Dierk Jorcke,张琚, Rainer Schneider, Helmut Klocker, Bernhard Auer, Manfred Schweiger. Characterization of Detergent-Solubilized Beef Liver Mitochodrial NAD?glycohydrolase and its Truncated Hydrosoluble Form. Biochemistry 张琚, Mathias Ziegler, Rainer Schneider, Helmut Klocker, Bernhard Auer, Manfred Schweiger. identification and purification of a bovine liver mitochondrial NAD?glycohydrolase. FEBS LETTERS杨睿，张立国，符蓉，王春雨，刘树业，石建党，张琚. 实时定量PCR技术检测前列腺癌微小转移的研究. 南开大学学报于林，王春雨，杨睿，王亮，石建党*，张琚. TAT-GFP-ERB融合蛋白的原核表达与鉴定. 南开大学学报周颖,杨睿,石建党*,刘杰,杜小玲,王克明,张琚*. BPH间质细胞增殖和表型转化与雌激素受体α表达的关系. 解剖学报苗琳,石建党*,周颖,杜小玲,吴荃,王克明,张琚*. BPH-1通过分泌PGE2上调前列腺间质细胞ERR?的表达. 中国生物化学与分子生物学报张智松,刘杰,杜小玲,段磊,张琚*,石建党. 雌激素快速激活MAPK途径促进前列腺间质细胞的增殖. 中国生物化学与分子生物学报Rui Yang, Yu-Xia Ma, Lin-Feng Chen, Ying Zhou1, Zhan-Po Yang, Yan Zhu, Xiao-Ling Du, Jian-Dang Shi*, Hong-Shun Ma, Ju Zhang*. Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia. Asian Journal of Andrology苗琳;周颖;石建党;杜小玲;焦鸿丽;张琚. 雌二醇通过TGFβ1促进前列腺间质细胞MMP-2的表达. 中国生物化学与分子生物学报 Miao, Jiandang Shi , Chun-Yu Wang, Yan Zhu, Xiaoling Du, Hongli Jiao, Zengnan Mo, Helmut Klocker, Chung Lee, . Estrogen receptor-related receptor alpha mediates up-regulation of aromatase expression by prostaglandin E2 in prostate stromal cells. Mol EndocrinolRui Yang, Da Xu, Jiandang Shi*, Helmut Klocker, Chung Lee, Ju Zhang*. Tanshinone IIA inhibits estrogen/androgen induced prostatic stromal hyperplasia. The Journal of Urology Yu, Jiandang Shi, Chun Yu Wang, Helmut klocker, Doris Mayer*, Ju Zhang*. Estradiol promotes the invasive potency of prostate cancer cells in a paracrine manner through stimulation of prostatic stromal cells. The Journal of Urology . Zhang, L. Wang, . Ma, . Du, J. Zhang*, . Shi* . nongenomic and genomic effects are involved in estradiol’s enhancing the phenotype of smooth muscle cells in cultured prostate stromal cells(AUA). The Journal of Urology . Zhou, . Xiao, R. Yang, . Shi*, . Du, J. Zhang*. Dynamic changes of stromal cell in the process of estrogen/androgen induced prostatic stromal hyperplasia in castrated rats. The Journal of Urology 贾金铭;马卫国;焦拥政;王家辉;罗少波;张琚;张智松. 癃必消胶囊对体外培养的人前列腺增生间质细胞作用机制的实验研究. 中国中西医结合杂志刘树业;杜智;商国强;贾艳慧;段缨;宋佐莉;张琚.. 肝癌中C53的表达及临床病理表现初探. 分子诊断与治疗杂志 马卫国;贾金铭;焦拥政;王家辉;罗少波;张琚;石建党;张智松. 癃必消胶囊对体外培养的人前列腺增生间质细胞Fibronectin和Collagen IV基因表达的影响. 中国男科学杂志马卫国;贾金铭;焦拥政;王家辉;罗少波;张琚;石建党;张智松. 癃必消胶囊对体外培养的人前列腺增生间质细胞TGF-β1和Smoothelin基因表达的影响. 中华男科学杂志袁庆东;肖向茜;梁承;张琚;赵建国. 电针用于治疗大鼠实验性前列腺增生症的机制研究. 中国康复医学杂志 樊官伟;王虹;张琚;高秀梅. 植物雌激素的临床价值. 国外医药（植物药分册）Iris Corvin,Christoph Maneschg,Marcus Bartsch Jr,Ju Zhang,Arnulf Stenzl,Georg Bartsch,Helmut Klocker.. Selective culture conditions for different types of primary human bladder cells. World J Urol 樊官伟，张琚，高秀梅. 选择性雌激素受体调节剂. 医学分子生物学杂志Yu Lin; Wang Chunyu; Shi Jiandang; Miao Lin; Du Xiaoling; Mayer Doris; Ju Zhang*. Estrogens Promote Invasion of Prostate Cancer Cells in a Paracrine Manner through Up-Regulation of Matrix Metalloproteinase 2 in Prostatic Stromal Cells. EndocrinologyLinjian Mo, Ju Zhang, Jiandang Shi, Qiang Xuan, Xiaoli Yang, Min Qin,Chung Lee, Helmut Klocker, Qingdi Quentin Li and Zengnan Mo. Human Kallikrein 7 Induces Epithelial?Mesenchymal Transition-like Changes in Prostate Carcinoma Cell. Anticancer Cui , ZhongLian Li , ErPeng Zhao , YanFeng Jia , DongHua Li , Ju Zhang and NaiQiang Cui. Overexpression of Sterol Carrier Protein 2 in Patients with Hereditary Cholesterol Gallstones. BMC Gastroenterology 彭雁飞，师莹，王亮，石建党*，杨小丽，张琚*. 用腺病毒载体包装不同分化程度平滑肌细胞特异性启动子的策略分离鉴定人前列腺间质细胞亚群. 南开大学学报Lin Yu, Jiandang Shi, Sa Cheng, Yan Zhu, Xiulan Zhao, Kuo Yang, Xiaoling Du,Helmut klocker，Xiaoli Yang，Ju Zhang*. Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells. Molecular Endocrinology杜小玲，宁召臣，王春雨，石建党，张琚*. 类固醇激素受体辅助调节因子ARA55和TGFβ1在前列腺癌细胞中作用分子机制的研究. 南开大学学报（自然科学版）Lin Miao, Sina Grebhardt, Jiandang Shi, Isabelle Peipe, Ju Zhang, Doris Mayer. Prostaglandin E2 stimulates S100A8 expression by activating protein kinaseA and CCAAT/enhancer-binding-protein-beta in prostate cancer cells . The International Journal of Biochemistry & Cell Biology --1

如果持续按摩男子前列腺可使他们出现射精和性高潮，故有人提出男子有阴茎高潮和前列腺高潮两种高潮形式。1978年塞弗里和贝内特发表了题为“关于女性射液和女性前列腺”的综述，他们确信女性的确存在一个在性刺激时能够肿胀的尿道旁或尿道周的结构。在获悉这一理论后许多妇科专家提出疑问，为什么我们在临床上从未发现这一构造？有的解释说常规的妇科检查不可能找到它，因为G点只有受到充分刺激时才会肿胀，这与泌尿科医生难得见到男子阴茎勃起是一个道理。阿迪亚哥在1981年报告了志愿者射出的液体和尿液样本的分析结果。受试者在48小时内不得与精液接触，她们在家中收集标本，当即冷冻并迅速送来化验。射液中的尿素水平和肌酸酐水平均显著低于尿液标本，而前列腺性磷酸酶和葡萄糖水平却高于尿液。人们过去从未在女性体内检验出这一男性特有的酶，但射液中从未发现前列腺素类物质。有的科学家发现27名不育症妇女在接受对G点的刺激后有10名有高潮射液。射液中的果糖水平显著高于尿液，但仍比男性精液中果糖含量低10-15倍。由于女性生殖系统也应有确保精子存活和活力的功能，所以，女性射液中含有果糖也是合情合理的事。