他汀类药物国外研究现状论文

Goal: Through to falls the blood fats medicine the market survey research is specially his sandbank class falls the blood fats medicine, obtains his sandbank class medicine market present situation, is helpful in gives the domestic drugs manufacture enterprise in to plan in his sandbank class medicine market sale to provide the basis. Research technique: Case law, literature law, visiting law data collection. Achievement: His sandbank class medicine hold fell the blood fats medicine major part market share, in which five is big his sandbank class to represent the medicine also to occupy the majority of his sandbank class medicine market share, moreover these five representatives the medicine main market share is held separately by the different multinational corporation. These five big respectively is places first on behalf of the medicine is Xin cuts down his sandbank, occupies 69.2% market shares, second is the atropic cuts down his sandbank, occupies 11.9% market shares; The following is in turn Pu cuts down his sandbank (11.3%), the fluorine cuts down his sandbank (6.8%), the Luo river cuts down his sandbank (approximately 1%). The distinction corresponds the leadership these five big on behalf of the medicine company is the American silent gram company, American Splendor Auspicious Company, Japan three altogether manufactures drugs the joint-stock company, Switzerland promises Chinese Corporation, the American silent gram company, this silent gram company also is simultaneously has two is big his sandbank class medicine the company. Conclusion: His sandbank class falls the blood fats medicine market is very attractive simultaneously also is a very fearful market, may see his sandbank class medicine through the material and the discussion the market share nearly all to hold by the overseas big company, simply does not have our existing space. The reason lies in his sandbank class medicine which the domestic drugs manufacture enterprise produces to fall the blood fats the length period of validity fruit and the import medicine is unable to compare, moreover in medicine propaganda dynamics also insufficient. Concrete saying, is must strengthen our medicine the quality, the marketing channel, like OTC market, hospital academic promotion, with the aid of medicine company middle men and so on. Must want to obtain the small space in his sandbank class market to have since childhood his sandbank as for example, the Luo river cuts down his sandbank to start, because his monopoly is not specially serious.

ASGR，可以通过减少相关的蛋白进行表达，这样就可以影响到脂质的合成，也会影响到脂质的代谢。

一项新的研究发现，给 心脏病 患者施以高剂量的他汀类药物，并不能够降低他们的心脏问题风险，那么他汀类药物的副作用你知道吗?下面是我为你整理的他汀类药物的副作用的相关内容，希望对你有用! 他汀类药物的副作用 1、他汀类药上市以来，全世界仅有600万人用过它;而拜斯亭作为他汀类药之一，因毒副作用过大导致30多个美国人失去生命， 从2002年进入中国药品市场以来，就已售出140多万粒。有多家外国药厂的他汀类药在中国医药市场上出售。 2、国外媒体纷纷报道他汀类药在降脂的同时，也带来了肝功下降、肌肉疼痛等毒副作用。而这一问题在德国拜耳公司宣布拜斯亭撤出市场之前，并没有引起国人的重视。人们关注的仅仅是他汀类药对人有利的一面。为了众多药品使用者的安全，药理学教授王振纲和心 内科 教授陈端霞联名撰文，再次提醒有少数患者使用他汀类药后因毒副作用而出现了临床症状。 3、国内外有关他汀类药毒副作用的病例，关于澳大利亚国家药物不良反应中心列举了两代、3个他汀类药，第一代为用培养法生产的辛伐他汀，第二代为用人工合成法生产的阿托伐他汀和西立伐他汀，两代药物之间由于结构有差异，临床效果和毒副作用也有一些区别。3个药物的剂量及引起CK变化的病人总数：西立伐他汀为19人，阿托伐他汀为20人，辛伐他汀30人。可以看出，西立伐他汀应用剂量虽小，但也能导致CK值严重升高，而用量较大的阿托伐他汀和辛伐他汀，导致CK值升高的程度更是惊人的。 4、西立伐他汀的剂量虽小，但引起肌痛发生率(6%)远远大于阿托伐他汀(0.2%)及辛伐他汀(1.1%)，而且西立伐他汀与贝特类调脂药合用，毒性大大增加(肌痛发生率17%)。在美国，已有30余名患者服用西立伐他汀钠(拜斯亭)后引起死亡，为此德国拜耳公司宣布：暂停销售所有剂量(0.3毫克至0.8毫克)的“拜斯亭”制剂。国家药品监督管理局已发出紧急 通知 ，禁止使用该药。另外国内已有患者服用辛伐他汀后，发生肌肉剧烈疼痛，中途停药。 他汀类药物的功能分类 1、他汀类药物还可抑制肝脏合成载脂蛋白B-100，从而减少富含甘油三酯AV、脂蛋白的合成和分泌。他汀类药物分为天然化合物(如洛伐他丁、辛伐他汀、普伐他汀、美伐他汀)和完全人工合成化合物(如氟伐他汀、阿托伐他汀、西立伐他汀、罗伐他汀、pitavastatin)是最为经典和有效的降脂药物，广泛应用于高脂血症的治疗。 2、他汀类药物除具有调节 血脂 作用外，在急性冠状动脉综合征患者中早期应用能够抑制血管内皮的炎症反应，稳定粥样斑块，改善血管内皮功能。延缓动脉粥样硬化(AS)程度、抗炎、保护 神经 和抗血栓等作用。 3、辛伐他汀(Simvastatin)是洛伐他汀(Lovastatin)的甲基化衍化物。美伐他汀(Mevastatin，又称康百汀，Compactin)药效弱而不良反应多未用于临床。主要用于制备它的羟基化衍化物普伐他汀(Pravastatin)。 他丁类 药物副作用 避免方法 1、常见的副作用:失眠,头痛, 腹泻 , 便秘 等。 2、较为严重的副作用:他汀类药物会引起相关肌病,造成非特异性肌肉或者关节痛。长期服用会造成横纹肌肉溶解。有少例患者会出现肝脏损伤、肾衰甚至严重的导致死亡。 3、如何避免他汀类药物的副作用:医生在开药时应该询问病人过敏史及 疾病 史,低密度脂蛋白LDL低于4.5mmol/L患者,不必冒险服用他汀类药物。 4、医生应随时掌握病人服药期间的不良反应,比如是否会引起肌肉疼痛,以及肌张力是否改变。同时也要注意患者的磷酸肌酸激酶(CK)及其同功酶的变化。 5、患者不要擅自轻易的提高他汀类药物的剂量。 6、高龄患者,体型虚弱瘦小这类患者极易有他汀类药物的副作用,应当谨慎使用。 7、慢性 肾功能 不全,尤其是 糖尿病 引起的肾功能不全者应当禁用。 猜你喜欢： 1. 常用他汀类药物有哪些 2. 降脂药空腹服用效果最佳吗 3. 吃柚子为什么不能吃他汀类药物 4. 高血脂药物副作用 5. 2016保健品市场分析