医学论文证据链翻译

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Objective To evaluate acute and long2term angiographic and clinical outcomes of longstent or multiple overlapped stents (length ≥ 20 mm) implantation for diffuse atherosclerosis lesions inoctogenarians. Methods Long stent or multiple overlapped stents implantation was performed on 111diffuse native coronary lesions ( Group O : 47 lesions in 44 octogenarians ; Group Y: 64 lesions in 58 patientsaged under 60) . Baseline demographic , lesion characteristic , angiographic and procedural details weresimilar in these 2 groups. Six2month clinical and angiographic follow2up was completed in all cases. In2hospital and long2term outcomes were evaluated. Results Procedure success was 100 %for both had in2hospital major adverse cardiac events (MACE) . There was no significant difference inangiographic binary restenosis ( ≥50 % diameter stenosis) rate between the groups at follow2up ( Group Ovs. Group Y, 1218 % vs1 1019 % at 32month , 2918 % vs. 2616 % at 62month , P > 0105) . The rates oftarget lesion revascularization and MACE at follow2up were less in Group Y, but it showed no statisticalsignificance (718 % vs. 1016 % and 816 % vs. 1114 % at 32month , 1516 % vs. 2314 % and 2017 % % at 62month , respectively , P > 0105) . Conclusions Long stent implantation for diffuse lesionsin octogenarians appears safe and feasible , with high procedural success and favorable long2term outcomes.

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呼吸链每一步的电子转移并非完全高效的，会导致电子逃逸并将氧气还原成超氧阴离子自由基，通过锰超氧化物歧化酶的作用转化为过氧化氢。这些活性氧簇（ROS）有可能破坏脂类，蛋白质，核酸，导致细胞功能障碍或死亡。 随着活性氧簇的增加，生理氧分压的电子传递链活动似乎被优化了，从而偏离了正常氧分压（在任一方向）。利用氧能量代谢是一把双刃剑：完整的葡萄糖氧化为二氧化碳和水和不完全氧化的葡萄糖转化成乳酸相比，大大增加了三磷酸腺苷产量，然而，电子传递存在着活性氧簇产生的潜在危险。因此，细胞氧气浓度必须通过稳态机制进行严密调节来控制氧输送和氧利用。

电子传递链的活动似乎是优化了生理警察乙和偏离正常的警察乙(在两个方向)会增加患ROS生产。利用O2对于能量代谢是一把双刃剑:完整的氧化葡萄糖与CO2和H2O大大增加了产量的ATP作为相比不完整的氧化葡萄糖与乳酸;然而,转移 提出了一种固有风险的电子的ROS生产。结果,细胞O2浓度一定很严格监管的通过自我平衡的机制,控制O2交付和O2利用率。

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