李娟医学论文

药物新剂型与新技术；中药新剂型与药代动力学；靶向给药系统、缓控释制剂和经皮吸收制剂的研究。近五年重点从事靶向给药制剂、新型药用高分子材料及细胞动力学研究、中药缓控释制剂及新技术的研究。拥有一支强有力的科研队伍，形成了自己科研工作的特色。 长期从事药物新剂型与创新药物制剂的开发研究工作，具有丰富的研发药物新制剂和组织开发药物新产品的综合能力。以靶向制剂、缓控释制剂和经皮吸收给药系统作为主要研究方向，近五年重点开展定时脉冲延释制剂的新技术研究、口服药物吸收机理的研究，自乳化给药系统及固体自微乳新剂型的研究；中药缓控释制剂及吸收药动学研究，应用Caco-2细胞模型和分子生物学技术，通过组织、器官和整体动物水平开展药物胃肠吸收机制、P-糖蛋白作用的研究。近几年从事纳米靶向载体材料的合成及在主动靶向给药系统应用的研究，开展抗肿瘤药物及载体靶向系统吸收动力学和体内靶向分布的研究。主持并完成国家863重大专项课题一项，课题编号：2004AA2Z3020，曾参加并完成国家自然科学基金一项，负责完成省纵向课题两项；主持并完成多项横向课题，获国家级新药证书两本；与国内制药企业合作的多项课题已获得较好的社会和经济效益。申请中国专利6项，已授权1项；近年来在国内外药学核心期刊发表学术论文30篇以上。主编药学专著2部，副主编专著1部，参编药剂学等专业著作10部。曾荣获中国药科大学授予教学改革课题《工业药剂学实验教学新体系的实践》奖、科技优秀奖、“献身教育的好教师” 、ISP科教优秀奖等荣誉证书；为中国临床药理学与治疗学杂志等国内知名期刊的同行审稿专家。指导硕士研究生22人，已毕业8人。

1. Huang G, Li Juan*, Fu H, Yan Z, Bu G, He X, Wang Y. Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transcript variants. Domestic Animal Endocrinology (on line: DOI:10-1016/ . ), 2012 (* 通迅作者)2. Wang Y, Huang G, Li Juan, Meng F, He X. Leung . Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280, 20123. Wang Y, Wang CY, Wu Y, Huang G, Li Juan, Leung F C. Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology 153, p1-14 (DOI: ), 20124. Wang Y, Li Juan, Kwok AHY, Ge W & Lueng FC. A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative Endocrinology 166: 200-210, 20105. Wang Y, Li Juan, C. Wang CY, Kwok AHY, Zhang X & Leung FC. Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31, 20106. Wang J, Wang Y, Li X, Li Juan* and Leung FC. Cloning, tissue distribution and functional characterization of chicken glucagon receptor. Poultry Science 87：2678-2688, 2008 (*通讯作者)7. Li Juan, Wang X, and Leung FC. The intragenomic polymorphism of a partially inverted repeat (PIR) in Gallus gallus domesticus, potential role of inverted repeats in satellite DNAs evolution. Gene 387:118-125, 20078. Wang Y, Li Juan, Wang CY, Kwok AH, and Leung FC. Epidermal growth factor receptor (EGFR) ligands in the chicken ovary: evidence for heparin-binding EGF-like growth factor (HB-EGF) as a potential oocyte-derived signal to control granulosa cell proliferation and HB-EGF and kit ligand expression. Endocrinology 148:3426-3440, 20079. Wang Y, Li Juan, Wang CY, Kwok AH, and Leung FC. Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor: evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148:2405-2416, 200710. Wang Y, Wang Z, Li Juan, Wang Y and Leung FC. Database for chicken full-length cDNAs. Physiol Genomics 28:141-145, 200711. Li Juan and Leung FC. A CR1 element is embedded in a novel tandem repeat (HinfI repeat) within the chicken genome. Genome 49:97-103, 200612. Wang CY, Wang Y, Li Juan and Leung FC. Expression profiles of growth hormone-releasing hormone and growth hormone-releasing hormone receptor during chicken embryonic pituitary development. Poultry Science 85:569-576, 200613. Guan Y, Peris JSM, Zheng B, Poon LLM, Chan KH, Zeng FY, Chan CWM, Chen JD, Chow KYC, Hon CC, Hui KH, Li Juan, Li VYY, Wang Y, Leung SW, Yuen KY, Leung FC. Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet 263:99-104, 200414. Zeng FY, Chan CW., Chen JD, Chow KYC, Hon CC, Hui KH, Li Juan, Li VYY, Wang Y, Leung SW, Yuen KY, Leung FC. The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849. Experimental Biology and Medicine 288:866-873, 200315. Wang X, Li Juan and Leung FC. Partially inverted tandem repeat isolated from pericentric region of chicken chromosome 8. Chromosome Res 10:73-82, 200216. Li Juan, Wang X and Leung FC. Partially inverted repetitive satellite DNA: A potential indicator for genetic homozygosity in chicken. 7th World Congress on Genetics Applied to Livestock Production 33:113-115, 2002