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执念梦浮生

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Objective: Through the study of animal experiments to observe the United Yishen soup benazepril 5 / 6 nephrectomized rats renal function improved efficacy and reduced TGF-β1 expression in renal tissue and other advantages, and to explore the soup Yishen possible to improve the renal function of mechanism of action. Methods: 1. Select SPF class healthy adult male SD rats with 50 only as the research object, adaptive feeding one weeks later, 10 randomly selected as the sham-operated group (A group), and the remaining 40 with 5 / 6 nephrectomy CRF-made law model. 2. After the success of model selection criteria in line with the study group 32 rats were divided into B: model group, 8; C groups: benazepril group 8; D group: the Chinese Medicines Board 8; E Group : Yishen Decoction United benazepril group referred to as traditional Chinese and western medicine group of eight, together with the A Group of 5 Group. 3. Successful modeling start after delivery, the groups were given corresponding drugs decoction. 4. The end of the experiment 24 hours after the detection of urinary protein and blood BUN, Scr, RBC, Hb, and renal histology observation and renal tissue TGF-β1 expression assay. Results: 1. The general situation: during the experiment, sham-operated rats demonstrated alertness, quick reaction, dense fur, clean and shiny, growth, consumption and the activities had no significant abnormalities, weight gain; model group was significant malnutrition, make them apathetic, slow activity, loss of appetite, fluffy fur, haggard Matte, died in the course of treatment at 2, probably because of renal failure due consideration; benazepril rats than sham-operated group spirit apathetic, slow activity, fur, fluffy; medicine the performance of rats with similar benazepril group; WM rats with sham-operated rats without much difference in general performance, but dry dark fur. 2. Of blood BUN, Scr impact: benazepril group, traditional Chinese medicine group, in the WM group significantly decreased BUN, Scr level, compared with the model group has significant difference (P <), but still high in sham-operated group; traditional Chinese and western medicine group and the Chinese medicine group, benazepril group has significant difference (P <); Chinese medicine group and the benazepril group was no significant difference (P> ). 3. Hematology impact: Chinese medicine group and the TCM-WM group was significantly increased blood RBC, Hb, compared with the model group has statistically significant difference (P <), but the difference between the two groups was not significant (P> ); benazepril group compared with the model group was no significant difference (P> ). 5. Pathologic changes, acceptance of renal rat subtotal excision were visible matrix hyperplasia, glomerular sclerosis, but the model group compared to the treatment group significantly lesser degree of glomerular sclerosis, one of traditional Chinese and western medicine to renal small ball for the lightest sclerosis; Immunohistochemistry results showed that the treatment group in renal tissue expression of TGF-β1 were significantly lower than model group (P <), and traditional Chinese and western medicine group can reduce the TGF-B1 in renal tissue Expression, and traditional Chinese medicine group and the benazepril group has statistically significant difference (P <). Conclusion: Yishen soup through Yiqi Jianpi, huoxuehuayu, dampness Xiexin Turbidimetry, CRF can reduce blood BUN, Scr, improve anemia and reduce proteinuria, can be reduced effectively with 5 / 6 nephrectomy-induced CRF rat kidney tissue expression of TGF-β1, thereby reducing the accumulation of ECM, slowing the development of renal fibrosis, and delay the progress of CRF. Fully Yishen soup has a good anti-renal fibrosis, but also after the United benazepril better efficacy.

124 评论

圆满的满

Objective To evaluate acute and long2term angiographic and clinical outcomes of longstent or multiple overlapped stents (length ≥ 20 mm) implantation for diffuse atherosclerosis lesions inoctogenarians. Methods Long stent or multiple overlapped stents implantation was performed on 111diffuse native coronary lesions ( Group O : 47 lesions in 44 octogenarians ; Group Y: 64 lesions in 58 patientsaged under 60) . Baseline demographic , lesion characteristic , angiographic and procedural details weresimilar in these 2 groups. Six2month clinical and angiographic follow2up was completed in all cases. In2hospital and long2term outcomes were evaluated. Results Procedure success was 100 %for both had in2hospital major adverse cardiac events (MACE) . There was no significant difference inangiographic binary restenosis ( ≥50 % diameter stenosis) rate between the groups at follow2up ( Group Ovs. Group Y, 1218 % vs1 1019 % at 32month , 2918 % vs. 2616 % at 62month , P > 0105) . The rates oftarget lesion revascularization and MACE at follow2up were less in Group Y, but it showed no statisticalsignificance (718 % vs. 1016 % and 816 % vs. 1114 % at 32month , 1516 % vs. 2314 % and 2017 % % at 62month , respectively , P > 0105) . Conclusions Long stent implantation for diffuse lesionsin octogenarians appears safe and feasible , with high procedural success and favorable long2term outcomes.

298 评论

兜兜兜尔

血糖升高对出血性脑卒中(hemorrhagic apoplexy)的发生发展有极其重要的影响,不但作为重要危险因素参与HA的起始,导致疾病发病率增高,而且对HA发生后病理过程有促进作用,使血肿体积扩大,加重水肿,加重功能损害,影响预后。Hyperglycemia has a very important impact on the occurrence and development of hemorrhagic stroke (hemorrhagic apoplexy). It not only acts as an important risk factor in the initiation of HA, but also increases the incidence of disease, and promotes the pathological process of HA, enlarges the volume of hematoma, aggravates edema, aggravates functional damage, and affects prognosis.高血糖参与HA的发生机制是多方面的,包括:脂代谢异常、颈动脉重塑、内皮功能障碍、血小板功能异常、高凝状态、胰岛素抵抗。而高血糖扩大梗死面积,促进HA发展主要与致酸中毒、缺血损伤区域细胞凋亡等机制有关。Hyperglycemia is involved in the pathogenesis of HA in many aspects, including: abnormal lipid metabolism, Carotid Remodeling, endothelial dysfunction, platelet dysfunction, hypercoagulability, insulin resistance. However, hyperglycemia can enlarge the infarct area and promote the development of HA, which is mainly related to the mechanism of acidosis and apoptosis in ischemic injury area.血管内皮生长因子(VEGF)和环氧合酶(COX-2)与脑血管病的关系,已引起人们的重视。血管内皮生长因子的突出作用是诱导体内血管形成,提高血管通透性;近年来发现它也有刺激神经元、胶质细胞、轴突的生长和成活的作用。环氧合酶(cyclooxygenase,COX),是催化花生四烯酸(arachidonic acid,AA)合成前列腺素(prostgalandin,PG)以及血栓素(thromboxan,TX)的限速酶。其中COX-1为结构型,存在于大多数组织中,催化生成维持正常结构的PG;COX-2为诱导型,在生理状态下,COX-2在大多数组织中以极低拷贝数表达。但IL-1、TNF等许多炎症刺激因子均可诱导COX-2表达。但目前有关血管内皮生长因子和环氧合酶的研究多集中在与脑缺血的关系上,而关于脑出血后脑水肿的动态变化与VEGF、COX-2表达的相关性研究却不多。The relationship between vascular endothelial growth factor (VEGF) and cyclooxygenase (COX-2) and cerebrovascular diseases has attracted people's attention. In recent years, it has been found that vascular endothelial growth factor can stimulate the growth and survival of neurons, glial cells and axons. Cyclooxygenase (COX) is a rate limiting enzyme that catalyzes the synthesis of prostaglandin (PG) and thromboxane (TX) from arachidonic acid (AA). COX-1 is a structural type, which exists in most tissues and catalyzes the generation of PG maintaining normal structure; COX-2 is an inducible type, which is expressed in a very low copy number in most tissues under physiological conditions. But many inflammatory factors such as IL-1 and TNF can induce COX-2 expression. However, at present, the researches on VEGF and COX-2 are mostly focused on the relationship with cerebral ischemia, but few on the relationship between the dynamic changes of brain edema and the expression of VEGF and COX-2 after cerebral hemorrhage.在认识到高血糖对脑出血损伤危害性同时,控制血糖水平治疗即成为脑血管病治疗手段之一,特别是采用胰岛素降低血糖水平纳入急性脑卒中治疗指南。已有研究发现胰岛素对急性期脑出血周围脑组织的缺血性损伤有保护作用。可能机制为:现已发现脑中存在胰岛素受体,胰岛素可与胰岛素受体结合,降低脑细胞对糖的摄取,从而降低脑细胞内糖的储存,减少乳酸产生的底物,从根本上纠正细胞酸中毒;同时胰岛素还可以降低外周血糖浓度,增加出血周围水肿带的有效血供,造成相对低血糖高灌流状态,从而对脑损害产生改善作用。In recognition of the harm of hyperglycemia to cerebral hemorrhage, the control of blood glucose level has become one of the treatment methods of cerebrovascular disease, especially the use of insulin to reduce blood glucose level has been included in the treatment guidelines of acute stroke. It has been found that insulin has a protective effect on the ischemic injury of brain tissue around acute cerebral hemorrhage. The possible mechanisms are as follows: it has been found that there is insulin receptor in the brain, insulin can combine with insulin receptor, reduce the uptake of sugar by brain cells, thus reduce the storage of sugar in brain cells, reduce the substrate produced by lactic acid, fundamentally correct cell acidosis; at the same time, insulin can also reduce the concentration of peripheral blood sugar, increase the effective blood supply of edema zone around hemorrhage, resulting in relatively low blood supply Hyperperfusion of blood glucose can improve brain damage.为了解这两种细胞因子与糖尿病合并脑出血损伤的关系,本研究在糖尿病模型的基础上,拟通过自体血注入法建立稳定的大鼠脑出血的动物模型,在此基础上动态观察脑出血后行为学和脑含水量的变化趋势,分析VEGF和COX-2在出血后脑组织中的分布特点和表达变化,进而探讨VEGF和COX-2在脑出血后脑组织损伤中的作用和意义,对比糖尿病大鼠和正常血糖大鼠脑水肿体积的差别,初步观察此二因子在糖尿病大鼠和正常血糖大鼠脑出血表达的差异,以期为脑出血的治疗提供新的方法和思路。In order to understand the relationship between these two cytokines and the injury of cerebral hemorrhage in diabetes mellitus, this study is to establish a stable animal model of cerebral hemorrhage by autogenous blood injection on the basis of diabetes model. On this basis, dynamic observation of the change trend of behavior and brain water content after cerebral hemorrhage is made, and the distribution characteristics and expression changes of VEGF and COX-2 in brain tissue after hemorrhage are analyzed, Furthermore, to explore the role and significance of VEGF and COX-2 in brain tissue injury after cerebral hemorrhage, to compare the difference of brain edema volume between diabetic rats and normal glucose rats, and to preliminarily observe the difference of expression of VEGF and COX-2 in cerebral hemorrhage between diabetic rats and normal glucose rats, in order to provide new methods and ideas for the treatment of cerebral hemorrhage.材料与方法Materials and methods1. 实验动物和分组1. Experimental animals and groups健康成年雄性Wistar大鼠,共96只,体重250~280克,由郑州大学实验动物中心提供。按照随机化的原则将实验动物分为4组,即假手术组、正常血糖组、高血糖组和胰岛素干预组。每组均设4个时间点:6h、24h、72h、7d。每个时间点设6只大鼠。96 healthy adult male Wistar rats weighing 250-280 g were provided by the experimental animal center of Zhengzhou University. According to the principle of randomization, the experimental animals were divided into four groups: sham operation group, normal blood glucose group, hyperglycemia group and insulin intervention group. Each group had four time points: 6h, 24h, 72h, 7d. Six rats were set at each time . 高血糖大鼠模型制作及胰岛素干预方法2. Establishment of hyperglycemia rat model and insulin intervention参照STZ诱导法制备高血糖大鼠模型。以STZ 60mg/kg,对高血糖及胰岛素干预组大鼠单次腹腔注射。大鼠正常血糖值为4一6mmol/L,注射后一周检测血糖≥为成功模型备选用。高血糖模型成功后,予干预组大鼠普通胰岛素,腹壁皮下注射,3次/d,4U/次,连用3天,测血糖值达正常范围。The hyperglycemia rat model was established by STZ induction. STZ (60 mg / kg) was used for single intraperitoneal injection in the hyperglycemia and insulin intervention group. The normal blood glucose value of rats was 4-6mmol / L, and the blood glucose ≥ was detected one week after injection as the successful model. After the success of hyperglycemia model, rats in the intervention group were given insulin, subcutaneous injection of abdominal wall, 3 times a day, 4U a time, for 3 days, and the blood glucose value reached the normal range.(论文翻译由学术堂提供)

360 评论

欣欣公主Q

医学论文翻译挺难的,没有一点的水平完全翻译不过来,建议还是找机构,让清北医学翻译帮忙把。

301 评论

家有一宝C

医学论文翻译一般较多的是医学论文的摘要翻译,即把医学论文的摘要翻译成英文,在国外期刊上发表都会要求整篇论文翻译成英文。一、在相关专业医学论文翻译中,要达到表意准确,必须了解相关领域的知识,熟练掌握同一概念的中英文表达法。单纯靠对语言的把握也能传达双方的语言信息,但在运用语言的灵活性和准确性两方而部会受到很大限制。要解决这个问题,译者就要努力熟悉这个领域的相关知识,比如,因此了解相关领域知识,在翻译过程中对翻译人员的语言理解力和医学论文翻译质量都有很大帮助。二、医学论文翻译的翻译标准。医学论文翻译标准是翻译实践的准绳和衡量译文好坏的尺度。关于翻译的标准,历来提法很多。有的主张“信、达、雅”,有的主张“信、顺”等等。但有一点是共同的,即一切译文都应包括原文思想内容和译文语言形式这两方面。>为此,在进行医学论文翻译时应坚持两条标准:>(一)忠实。应忠实于原内容,准确地、完整地、科学地表达原文的内容不得有任何篡改、歪曲、遗漏或任意增删的现象。内容通常指文中所叙述的事实,说明的事理,作者在叙述、说明和描写过程中所反映的思想、观点、立场和所流露的感情等。>(二)通顺。医学论文翻译语言必须通顺易懂,符合规范,用词造句应符合本族语的习惯,要用民族的、科学的、大众的语言,以求通顺易懂。不应有文理不通、结构混乱、逐词死译和生硬晦涩等现象。三、过程中要体现语言结构特色(一)词汇上的特点1. 词义演变。医学论文翻译的专业词汇通常都出现在特定领域,它一般分为两类:一类是某一专业特有的词汇,这类词汇一般具有一词对应一义的特点;还有一类由普通词汇演变而来的专业词汇,这类词汇一词多义,必须应用语言学知识和专业知识综合分析,在翻译实践中不断丰富扩大。2. 词缀。比如:从词源学的角度来看,在医学英语词汇中,希腊语、拉丁语的词素占有极高比率。据Oscar 的统计,一万个医学词汇约有46%来自拉丁语;来自希腊语,希腊、拉丁词素是医学英语词汇的重要基础。希腊语、拉丁语拥有极丰富的词缀,且每个词缀都有其固定意义,可与不同的词干组成无数新词。3. 动词多使用规范的书面语。英语词汇从语体的特点来分,可分为普通词汇和正式词汇。普通词汇大部分是英语本族语,常用于英语口语和文学作品中,正式词汇大部分是外来词,常用于科技、经济、政治等较正式的文章中。(二)大量使用名词化结构1. 医学论文中大量使用名词化结构 (Nominalization)是医学论文翻译的特点之一,因为文体要求行文简洁、表达客观、内容确切、信息量大、强调存在的事实,而非某一行为。2. 大量使用长句和定语从句医学论文翻译中大量使用长句和定语从句,在论证上起到连接信息和强调信息的作用。3. 名词作定语和缩写词使用频繁。医学论文翻译中要求行文简炼、结构紧凑,名词作定语和缩写词的频繁使用,简化了句型,增大了信息密度。4. 广泛使用被动语态。医学论文中侧重叙事推理,强调客观准确,第一、二人称使用过多,会造成主观臆断的印象。因此尽量使用第三人称叙述,采用被动语态。四、医学论义翻译的翻译方法。医学论义翻译要提高翻译量,使译文达到准确、通顺这两个标准,就必须运用医学论文翻译技巧。医学论文翻译技巧指翻译过程中用词造句的处理方法,如词义的引申、增减、词类转换和领域术语的翻译方法等。(一)引申法。医学论文翻译时,有时会遇到某些词在英语词典上找不到适当的词义,如果任意硬套或逐词死译,会使医学论文翻译生硬晦涩,不能确切表达原意,甚至造成误解。这时则可以在不脱离该英语词义的前提下,灵活选择怡当的汉语词语或词组译出。(二)增词译。由于英汉两种语言在词语用法、句子结构和表达方式上有许多差异,医学论文翻译时往往需要增加一些原文中没有的词,使译文通顺而且更加忠实地表达原文的意思。增词译的情况有两种。一种是根据意义或修辞的需要,如增加表示时态意义的词,增加英语不及物动词隐含的宾语意义的词。另一种是根据句法上的需要,增加原文句子中所省略的词。(三)省略译。省略译是将原文中的宥些词省略不译,以使译文符合语言习惯。(四)词类转换英译汉时,常常需要将英语句子中属于某种词类的词,译成另一种词类的汉语词,以使译文通顺自然,符合汉语的表达习惯。这种翻译处理方法就是转换词性法,简称词类转换。(五)领域专业术语的译法。医学论文翻译中有大量的术语,而且科学性、专业性很强。领域专业术语的译法有意译、音译、象形译和原形译四种。总之,医学论文的翻译需要专业的医学学科知识和大量对学术名词的积累。希望能帮到你,也可以自己去找相关的机构帮你

207 评论

大白包小白

据学术堂了解,在医学论文的翻译过程中,不少医学工作者表示中医术语翻译好难。翻译中医术语,不仅需要具备翻译功底,还须熟知中医学理论和扎实的古汉语知识。所以,难是可以理解的。为了帮助医学工作者解决烦恼,下面我们来谈谈医学术语的翻译方法。一、科技英语常用构词法。在科技英语构词中,普遍运用的是复合法、缀合法、缩合法、首字母缩略等,这些方法在中医术语翻译时均可借鉴。1、复合法这类术语在中医术语翻译中占了很大的比例,其含义大多是各个词含义的叠加。采用这种译法的优点是容易找到对应词,结构明了,易于理解。缺点是译文往往不够简洁。2、缀合法此类术语的含义为词缀与词干意义的相加,特点是简洁,专业性强,与西医术语的可比性强,便于学术交流。但在目前中医术语翻译中,这类词的使用比例并不高,如针灸。3、缩合法其含义通常是构成该词的两个部分的词语意义相加,其特点类似缀合法。例如针压。4、首字母缩略这种方法在科技英语(包括医学英语)中使用得非常广泛,但在中医英语中却很少使用。目前被普遍接受的只有”中医”一词。当然,也有学者在这方面做了有益的尝试,如将温病缩略为。首字母缩略是一种非常便捷的构词方式,可提高单位词汇的信息量。但是,如何运用这一方法使中医术语趋于简洁,规范,还有待进行深入的研究。二、其他翻译方法1、词性的转换由于中文和英文的语言结构,表达方式不同,在翻译时要将中医术语的结构进行转换。较常用的方法是将中文的主谓结构,动宾结构转换成英文中的名词性词组或非限定动词词组。例如 止痛等。对症状的描述也多采用类似的方法。由于症状表示的是一种状态,而非具体动作,其中文可采用主谓或动宾等词组来描述,而在英语中则常采用名词(词组)或动名词(词组)的形式。如盗汗等。2、结构调整中医术语大多形成于中国古代,故语言形式上保留了古汉语的特点,讲究工整对仗。但在译成英语时,往往需要对这类结构进行调整,采用符合目的语语言习惯的结构,实现意义上的忠实。如神疲肢倦,心悸怔忡等。3、音译法由于东西方文化和中西医理论之间存在很大的差异,所以有不少中医术语很难在西医(英语)中找到对应的词,用意译的方法则译文过于冗长,不符合术语简洁精练的要求。在这种情况下,采用音译不失为一种可取的选择,必要时可加以注释,以弥补音译的不足。例气一,气功一,阴阳一。气是中医理论中的一个重要概念,它既可以指人体的生命物质,也可以指人体的生理功能。用音译法来翻译,则最直接,最简洁地反映出了”气”的真实内涵。 基本上,医学工作者翻译医学术语,可以从以上两种方法出发。当然,在翻译的过程中也要注意实际的语境要求。最后,希望这两种翻译方法可以帮助到大家。

223 评论

欧罗百利

Objective: Through the study of animal experiments to observe the United Yishen soup benazepril 5 / 6 nephrectomized rats renal function improved efficacy and reduced TGF-β1 expression in renal tissue and other advantages, and to explore the soup Yishen possible to improve the renal function of mechanism of action. Methods: 1. Select SPF class healthy adult male SD rats with 50 only as the research object, adaptive feeding one weeks later, 10 randomly selected as the sham-operated group (A group), and the remaining 40 with 5 / 6 nephrectomy CRF-made law model. 2. After the success of model selection criteria in line with the study group 32 rats were divided into B: model group, 8; C groups: benazepril group 8; D group: the Chinese Medicines Board 8; E Group : Yishen Decoction United benazepril group referred to as traditional Chinese and western medicine group of eight, together with the A Group of 5 Group. 3. Successful modeling start after delivery, the groups were given corresponding drugs decoction. 4. The end of the experiment 24 hours after the detection of urinary protein and blood BUN, Scr, RBC, Hb, and renal histology observation and renal tissue TGF-β1 expression assay. Results: 1. The general situation: during the experiment, sham-operated rats demonstrated alertness, quick reaction, dense fur, clean and shiny, growth, consumption and the activities had no significant abnormalities, weight gain; model group was significant malnutrition, make them apathetic, slow activity, loss of appetite, fluffy fur, haggard Matte, died in the course of treatment at 2, probably because of renal failure due consideration; benazepril rats than sham-operated group spirit apathetic, slow activity, fur, fluffy; medicine the performance of rats with similar benazepril group; WM rats with sham-operated rats without much difference in general performance, but dry dark fur. 2. Of blood BUN, Scr impact: benazepril group, traditional Chinese medicine group, in the WM group significantly decreased BUN, Scr level, compared with the model group has significant difference (P <), but still high in sham-operated group; traditional Chinese and western medicine group and the Chinese medicine group, benazepril group has significant difference (P <); Chinese medicine group and the benazepril group was no significant difference (P> ). 3. Hematology impact: Chinese medicine group and the TCM-WM group was significantly increased blood RBC, Hb, compared with the model group has statistically significant difference (P <), but the difference between the two groups was not significant (P> ); benazepril group compared with the model group was no significant difference (P> ). 5. Pathologic changes, acceptance of renal rat subtotal excision were visible matrix hyperplasia, glomerular sclerosis, but the model group compared to the treatment group significantly lesser degree of glomerular sclerosis, one of traditional Chinese and western medicine to renal small ball for the lightest sclerosis; Immunohistochemistry results showed that the treatment group in renal tissue expression of TGF-β1 were significantly lower than model group (P <), and traditional Chinese and western medicine group can reduce the TGF-B1 in renal tissue Expression, and traditional Chinese medicine group and the benazepril group has statistically significant difference (P <). Conclusion: Yishen soup through Yiqi Jianpi, huoxuehuayu, dampness Xiexin Turbidimetry, CRF can reduce blood BUN, Scr, improve anemia and reduce proteinuria, can be reduced effectively with 5 / 6 nephrectomy-induced CRF rat kidney tissue expression of TGF-β1, thereby reducing the accumulation of ECM, slowing the development of renal fibrosis, and delay the progress of CRF. Fully Yishen soup has a good anti-renal fibrosis, but also after the United benazepril better efficacy.

253 评论

Luck丶美人蕉

NaQing sex deep overburden front teeth tooth meets the clinical experience treatmentAbstract: objective to investigate NaQing sexual front teeth tooth overburden match not deep treatment of factors, correction method and the matters needing attention. Methods selection NaQing sex deep overburden front teeth and 18 cases, are not case tooth correction. Results treatment completion time 15 to 21 months, average months. Correction by first teeth together, facial side cover normal appearance was coordination. Conclusion anterior tooth NaQing sex should be repeated in deep choosing good indications fits the tooth under treatment.

89 评论

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